Assessment of Endometrial Pattern and Sub-endometrial Vascularity in ICSI Outcome

Infertility Clinical Trial

Official title:

Assessment of Endometrial Pattern and Sub-endometrial Vascularity in Prediction of Pregnancy Rate in ICSI

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03683771
• Other study ID #: ICSI vascularity
• Status: Recruiting
• Start date: September 28, 2018
• Est. completion date: February 20, 2019

Study information

• Verified date: January 2019
• Source: Aljazeera Hospital
• Contact: Mahmoud Alalfy
• Phone: 01002611058
• Email: mahmoudalalfy[@]ymail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Despite constant progress in in vitro fertilization (IVF) techniques and ovarian stimulation, pregnancy and embryo implantation rates remain modest . The phenomenon of embryo implantation depends both on the embryo itself and on endometrial receptivity

Description:

A favorable uterine medium is necessary for embryo implantation, but endometrial receptivity can be negatively affected by ovarian stimulation . Study of endometrial receptivity is especially limited in the context of IVF cycles .

Biopsy of the endometrium cannot be considered during the treatment, and this has encouraged the development and use of ultrasonography and Doppler-like non-invasive methods to evaluate ovarian response to the stimulation and uterine receptivity .

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 120
• Est. completion date: February 20, 2019
• Est. primary completion date: February 15, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 20 Years to 40 Years

Eligibility

Inclusion Criteria:

• Maternal age from 20 to 40 years. Women with BMI range from 20 - 35 Women diagnosed with primary infertility

Exclusion Criteria:

Maternal chronic medical disorder (diabetes mellitus or hypertension). Women diagnosed with autoimmune diseases or antiphospholipid syndrome

Related Conditions & MeSH terms

• Infertility

Intervention

Diagnostic Test:
• Transvaginal US with Doppler study
Transvaginal Ultrasound with doppler study on endometrium will be made

Locations

Country	Name	City	State
Egypt	Kasralainy hospital	Cairo
Egypt	Algazeerah and Kasralainy hospital	Giza

Sponsors (3)

Lead Sponsor	Collaborator
Aljazeera Hospital	Kasr El Aini Hospital, National research centre

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The number of patients who will have positive pregnancy rate	patients who will get pregnant in ICSI cycle with measuring their doppler indices before ovum pick up	within 2 months