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NCT03677492 Clinical Trial

Supplementing Intracytoplasmic Sperm Injection Handling Medium With Cytochalasin D ( ICSI-CD)

Infertility Clinical Trial

Official title:
Cytochalasin D Supplementation to ICSI Handling Medium

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03677492
Other study ID # IbnSinaIVF-ICSI-CD
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date September 25, 2018
Est. completion date April 30, 2019

Study information
Verified date May 2019
Source Ibn Sina Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. Cytochalasin D serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. Using Cytochalasin D during ICSI could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes.

Recruitment information / eligibility
Status Completed
Enrollment 300
Est. completion date April 30, 2019
Est. primary completion date April 25, 2019
Accepts healthy volunteers No
Gender Female
Age group 18 Years to 42 Years
Eligibility Inclusion Criteria:

- ICSI indicated participants

Exclusion Criteria:

-

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Medium Supplemented with Cytochalasin D
A medium with in-house supplementation of Cytochalasin D to decrease oocyte degeneration after ICSI and improve the survival rate

Locations
Country Name City State
Egypt Banon Assiut Assiut
Egypt IbnSina IVF Center, IbnSina Hospital Sohag

Sponsors (1)
Lead Sponsor Collaborator
Ibn Sina Hospital

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Oocyte survival rate 6 days of culture
Secondary Fertilization rate 6 days of culture
Secondary Blastocyst formation rate 6 days of culture
Secondary Embryo utilization rate 6 days of culture
Secondary Clinical pregnancy rate three months
Secondary Implantation rate 7 weeks
Secondary Ongoing pregnancy rate 12 weeks
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