Infertility Clinical Trial
Official title:
Effect of Gonadotropin Types and Indications on Homologous Intrauterine Insemination Success: A Study From 1251 Cycles and a Review of the Literature
In this study the investigators took the opportunity of having a large sample of IUI cycles
in a single centre to try to analyse the effect of stimulation protocols and of the
infertility origin on the results, taking in account the main confounding variables (female
age, IUI attempt rank, and sperm quality) on the clinical outcome.
All couples had undergone a standard infertility evaluation, which included medical history,
physical examination, and assessment of tubal patency by either hysterosalpingography or
laparoscopy and hormonal analysis on cycle day 3. A transvaginal ultrasound scan was
performed on the second day of the cycle. On the same day, ovarian stimulation was carried
out with recombinant FSH (follitropinrFSH; Gonal-F, MerckSerono, France,
orfollitropin;Puregon, MSD, France), urinary FSH (urofollitropin, Fostimon, France), orhMG
(menotropin, Menopur, France) atastarting dose of 75 IU/day from the second day of the cycle.
The main clinical outcome measures were clinical pregnancy and live-birth rates per cycle.
Clinical pregnancy was defined as the evidence of pregnancy by ultrasound examination of the
gestational sac at weeks 5-7.
Many studies have evaluated the predictive factors of IUI clinical outcomes, including the
female's age, the infertility duration, the rank of the attempt, and the sperm parameters
[10-16]. However, few studies have compared the pregnancy rates based on the used COS or on
the infertility type.
In this study the investigators took the opportunity of having a large sample of IUI cycles
in a single centre to try to analyse the effect of stimulation protocols and of the
infertility origin on the results, taking in account the main confounding variables (female
age, IUI attempt rank, and sperm quality) on the clinical outcome.
All couples had undergone a standard infertility evaluation, which included medical history,
physical examination, and assessment of tubal patency by either hysterosalpingography or
laparoscopy and hormonal analysis on cycle day 3. A transvaginal ultrasound scan was
performed on the second day of the cycle. On the same day, ovarian stimulation was carried
out with recombinant FSH (follitropinrFSH; Gonal-F, MerckSerono, France,
orfollitropin;Puregon, MSD, France), urinary FSH (urofollitropin, Fostimon, France), orhMG
(menotropin, Menopur, France) atastarting dose of 75 IU/day from the second day of the cycle.
The main clinical outcome measures were clinical pregnancy and live-birth rates per cycle.
Clinical pregnancy was defined as the evidence of pregnancy by ultrasound examination of the
gestational sac at weeks 5-7.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03607409 -
Role of Inhibin A as Biomarker for Ovarian Response for IVF Treatment
|
||
Recruiting |
NCT02312076 -
GnRHa for Luteal Phase Support in Long GnRHa Protocol Cycles
|
Phase 4 | |
Terminated |
NCT02161861 -
Improvement of IVF Fertilization Rates, by the Cyclic Tripeptide FEE - Prospective Randomized Study
|
N/A | |
Completed |
NCT03287479 -
Comparison of a Semi-automated Closed Vitrification System (Gavi®) With a Manual Open Vitrification Sytem (Cryotop®)
|
N/A | |
Terminated |
NCT03522350 -
Randomized Trial Comparing EmbryoScope With EmbryoScope+.
|
N/A | |
Completed |
NCT04496284 -
Embryo Transfer Outcomes After Vitrification With Slush Nitrogen Compared to Liquid Nitrogen
|
N/A | |
Completed |
NCT03623659 -
pArtiaL zonA pelluciDa Removal by assisteD hatchINg of Blastocysts
|
N/A | |
Completed |
NCT03895099 -
New Ovarian Stimulation With Random Start, Use of Progestin Protocol for Oocyte Donors
|
Phase 3 | |
Active, not recruiting |
NCT04142112 -
Randomized, Standard-Controlled, Study to Evaluate the Ohana IVF Sperm Preparation Kit, SPeRtility IVF Next Generation
|
N/A | |
Completed |
NCT03152643 -
Cumulative Live Birth Rates After Cleavage-stage Versus Blastocyst-stage Embryo Transfer
|
N/A | |
Recruiting |
NCT03683771 -
Assessment of Endometrial Pattern and Sub-endometrial Vascularity in ICSI Outcome
|
||
Recruiting |
NCT03161119 -
Comparing Two Different Embryo Transfer Catheters
|
N/A | |
Completed |
NCT04108039 -
Micronized Progesterone vs Gonadotropin-releasing Hormone (GnRH) Antagonist in Freeze-all IVF Cycles.
|
N/A | |
Completed |
NCT03677492 -
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Cytochalasin D ( ICSI-CD)
|
N/A | |
Completed |
NCT03678571 -
Oocyte Vitrification Aided With Latrunculin A
|
N/A | |
Completed |
NCT03678584 -
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Chaetoglobosin A ( ICSI-CA)
|
N/A | |
Completed |
NCT03678818 -
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Latrunculin A (ICSI-LA)
|
N/A | |
Completed |
NCT03678597 -
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Latrunculin B ( ICSI-LB)
|
N/A | |
Completed |
NCT03678610 -
Handling Medium for ICSI With Ionomycin and Latrunculin A
|
N/A | |
Completed |
NCT03678558 -
Oocyte Vitrification Aided With Cytochalasin B
|
N/A |