Infertility Clinical Trial
— ICSI-CBOfficial title:
Cytochalasin B Supplementation to ICSI Handling Medium
Verified date | August 2019 |
Source | Ibn Sina Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. Cytochalasin B serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. Using Cytochalasin B during ICSI could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes,
Status | Completed |
Enrollment | 987 |
Est. completion date | August 1, 2019 |
Est. primary completion date | July 20, 2019 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: - All ICSI candidates patients Exclusion Criteria: - No exclusion |
Country | Name | City | State |
---|---|---|---|
Egypt | IbnSina IVF Center | Sohag |
Lead Sponsor | Collaborator |
---|---|
Ibn Sina Hospital | Banoon IVF Center |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | oocyte survival rate | number of survived oocyte after intracytoplasmic sperm injection | 6 days of culture | |
Secondary | fertilization rate | number of fertilized oocytes per metaphase II injected | 6 days of culture | |
Secondary | blastocyst formation rate | number of formed blastocyst per fertilized oocyte | 6 days of culture | |
Secondary | embryo utilization rate | number of embryo transferred added to number of those cryopreserved per fertilized oocyte | 6 days of culture | |
Secondary | clinical pregnancy rate | number of women with a heartbeat at week 4 or more after embryo transfer | three months | |
Secondary | ongoing pregnancy rate | number of women with continued pregnancy after twelve weeks of gestation | four months |
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