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NCT03607409 Clinical Trial

Role of Inhibin A as Biomarker for Ovarian Response for IVF Treatment

Infertility Clinical Trial

Official title:
Role of Inhibin A as Biomarker for Ovarian Response to Stimulation With Gonadotropins for IVF Treatment

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03607409
Other study ID # 1806-ABU-043-BL
Secondary ID
Status Completed
Phase
First received
Last updated
Start date September 9, 2018
Est. completion date July 4, 2019

Study information
Verified date August 2019
Source IVI Middle East Fertility Clinic
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

To evaluate the role of Inhibin A as bio marker for the number of mature oocytes, compared to Estradiol

Description:

Inhibin A could be an improved biomarker regarding the number of expected mature oocytes compared to estradiol.

Recruitment information / eligibility
Status Completed
Enrollment 150
Est. completion date July 4, 2019
Est. primary completion date January 29, 2019
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria:

Patients undergoing ovarian stimulation with gonadotropins in either a GnRH-agonist or GnRH-antagonist for IVF treatment due to primary / secondary infertility.

Exclusion Criteria:

Patients undergoing a modified natural cycle stimulation protocol (Taymour cycle) Patients at risk for development of ovarian hyperstimulation syndrome (OHSS)

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
United Arab Emirates IVI Middle East Fertilty Clinic Abu Dhabi

Sponsors (2)
Lead Sponsor Collaborator
IVI Middle East Fertility Clinic Ansh Labs

Country where clinical trial is conducted

United Arab Emirates, 

References & Publications (3)

Abbara A, Vuong LN, Ho VNA, Clarke SA, Jeffers L, Comninos AN, Salim R, Ho TM, Kelsey TW, Trew GH, Humaidan P, Dhillo WS. Follicle Size on Day of Trigger Most Likely to Yield a Mature Oocyte. Front Endocrinol (Lausanne). 2018 Apr 25;9:193. doi: 10.3389/fendo.2018.00193. eCollection 2018. — View Citation

Hohmann FP, Laven JS, de Jong FH, Fauser BC. Relationship between inhibin A and B, estradiol and follicle growth dynamics during ovarian stimulation in normo-ovulatory women. Eur J Endocrinol. 2005 Mar;152(3):395-401. — View Citation

Schneyer AL, Fujiwara T, Fox J, Welt CK, Adams J, Messerlian GM, Taylor AE. Dynamic changes in the intrafollicular inhibin/activin/follistatin axis during human follicular development: relationship to circulating hormone concentrations. J Clin Endocrinol Metab. 2000 Sep;85(9):3319-30. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Number of mature oocytes Patients undergoing ovarian stimulation with gonadotropins 1 year
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