Infertility Clinical Trial
Official title:
Method for Determining Optimal FSH Dosage During in Vitro Fertilization (IVF)
During in vitro fertilisation (IVF) treatment, women receive hormone stimulation with
gonadotropins to induce growth of several ovarian follicles. Selecting the optimal dosage of
gonadotropin is important to avoid maturation of too few or too many follicles, which may
impair the chances of treatment success, lead to treatment cancellation, or serious side
effects.
Motivated by the lack of standardised procedures to estimate the optimal dosage of
gonadotropins, a patient-specific test has been developed to predict the optimal hormone
dosage. By measuring internalisation of gonadotropin by the patient's monocytes isolated form
the peripheral blood ex vivo, the Gonadotropin Removal Test determines whether a patient
needs increased or reduced hormon doses.
In this clinical study the investigators compare deviation from optimal outcome at oocyte
pick-up day in two patient groups. Optimal outcome of stimulation is defined as 10 oocytes
collected in the group of patients matching the inclusion criteria of the study.
The control group receives starting hormone dosage assigned by the clinician according to
standard clinical procedures. The intervention group receives starting hormone dosage
adjusted according to the results of the Gonadotropin Removal Test.
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