Infertility Clinical Trial
Official title:
Endometrial Injury for Unexplained Infertility: Randomized Case-control Study
Verified date | August 2016 |
Source | Benha University |
Contact | n/a |
Is FDA regulated | No |
Health authority | Egypt: Ministry of Higher Education |
Study type | Interventional |
One hundred and twenty women with unexplained infertility were included in the study.
Divided randomly into two groups:
Group I: (60 patients): (control group)
Group II (60 patients): (study group)
All the patients received (CC) and human menopausal gonadotropin. On day 5 of the cycle,
Doppler examination was performed to all patients. Also on day 5, but only for group (II)
patients, local endometrial injury was performed. Doppler studies was repeated, for all our
patients, on the same day of prescribing human chorionic gonadotropin
Status | Completed |
Enrollment | 120 |
Est. completion date | July 2016 |
Est. primary completion date | February 2016 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 20 Years to 35 Years |
Eligibility |
Inclusion Criteria: - age Between 20 - 35 years - Body mass index 18-29 kg/m2 - primary infertility for more than two years, and planning for IVF/intracytoplasmic sperm injection trial - Normal ovulation confirmed by previous US - Normal hormonal profile follicle stimulating hormone, luteinizing hormone, and prolactin, Antimullerian hormone (AMH) more than 1 ng/ml - Normal hysterosalpingography - Normal laparoscopic finding - normal semen analysis, according to World Health Organization 2010 Exclusion Criteria: - Absence of inclusion criteria - History of previous laparotomy - Patients with history which may suggest endometriosis - Associated chronic medical conditions e.g. cardiac disease, diabetes, renal disease… etc. |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Egypt | Benha university hospital? | Benha | Alqalubia |
Lead Sponsor | Collaborator |
---|---|
Benha University |
Egypt,
Maged AM, Al-Inany H, Salama KM, Souidan II, Abo Ragab HM, Elnassery N. Endometrial Scratch Injury Induces Higher Pregnancy Rate for Women With Unexplained Infertility Undergoing IUI With Ovarian Stimulation: A Randomized Controlled Trial. Reprod Sci. 2016 Feb;23(2):239-43. doi: 10.1177/1933719115602776. Epub 2015 Sep 3. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | measurement of uterine pulsatility index | measurement of uterine pulsatility index at day of human chorionic gonadotropin administration. | one week | Yes |
Primary | measurement of uterine resistance index | measurement of uterine resistance index at day of human chorionic gonadotropin administration. | one week | Yes |
Primary | sub endometrial blood flow | sub endometrial blood flow between study and control groups on the day of human chorionic gonadotropin, administration. | one week | Yes |
Primary | Spiral artery Doppler pulsatility indices | Spiral artery Doppler pulsatility indices between study and control groups on the day of human chorionic gonadotropin administration. | one week | Yes |
Primary | Spiral artery Doppler resistance indices | Spiral artery Doppler resistance indices between study and control groups on the day of human chorionic gonadotropin administration. | one week | Yes |
Secondary | pregnancy rate between the study and the control group | detection of serum pregnancy tests for both groups | 3 weeks | Yes |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03607409 -
Role of Inhibin A as Biomarker for Ovarian Response for IVF Treatment
|
||
Recruiting |
NCT02312076 -
GnRHa for Luteal Phase Support in Long GnRHa Protocol Cycles
|
Phase 4 | |
Terminated |
NCT02161861 -
Improvement of IVF Fertilization Rates, by the Cyclic Tripeptide FEE - Prospective Randomized Study
|
N/A | |
Completed |
NCT03287479 -
Comparison of a Semi-automated Closed Vitrification System (Gavi®) With a Manual Open Vitrification Sytem (Cryotop®)
|
N/A | |
Terminated |
NCT03522350 -
Randomized Trial Comparing EmbryoScope With EmbryoScope+.
|
N/A | |
Completed |
NCT04496284 -
Embryo Transfer Outcomes After Vitrification With Slush Nitrogen Compared to Liquid Nitrogen
|
N/A | |
Completed |
NCT03623659 -
pArtiaL zonA pelluciDa Removal by assisteD hatchINg of Blastocysts
|
N/A | |
Completed |
NCT03895099 -
New Ovarian Stimulation With Random Start, Use of Progestin Protocol for Oocyte Donors
|
Phase 3 | |
Active, not recruiting |
NCT04142112 -
Randomized, Standard-Controlled, Study to Evaluate the Ohana IVF Sperm Preparation Kit, SPeRtility IVF Next Generation
|
N/A | |
Completed |
NCT03152643 -
Cumulative Live Birth Rates After Cleavage-stage Versus Blastocyst-stage Embryo Transfer
|
N/A | |
Recruiting |
NCT03683771 -
Assessment of Endometrial Pattern and Sub-endometrial Vascularity in ICSI Outcome
|
||
Recruiting |
NCT03161119 -
Comparing Two Different Embryo Transfer Catheters
|
N/A | |
Completed |
NCT04108039 -
Micronized Progesterone vs Gonadotropin-releasing Hormone (GnRH) Antagonist in Freeze-all IVF Cycles.
|
N/A | |
Completed |
NCT03678558 -
Oocyte Vitrification Aided With Cytochalasin B
|
N/A | |
Completed |
NCT03678610 -
Handling Medium for ICSI With Ionomycin and Latrunculin A
|
N/A | |
Completed |
NCT03678818 -
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Latrunculin A (ICSI-LA)
|
N/A | |
Completed |
NCT03678597 -
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Latrunculin B ( ICSI-LB)
|
N/A | |
Completed |
NCT03677492 -
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Cytochalasin D ( ICSI-CD)
|
N/A | |
Completed |
NCT03678571 -
Oocyte Vitrification Aided With Latrunculin A
|
N/A | |
Completed |
NCT03678584 -
Supplementing Intracytoplasmic Sperm Injection Handling Medium With Chaetoglobosin A ( ICSI-CA)
|
N/A |