Infertility Clinical Trial
Official title:
Low-dose Growth Hormone Supplementation Increases Clinical Pregnancy Rate in Poor Responders Undergoing in Vitro Fertilisation.
The objective of this study is to assess whether a low dose of GH supplementation (0.5 IU/day) increases clinical pregnancy rates in women with a history of POR who failed to become pregnant in two previous IVF cycles.
The investigators aim to study the impact of a low-dose growth hormone (GH) supplementation
in pregnancy rates in poor responders in a prospective, self-controlled study of 64 poor
responders to previous IVF cycles who failed to achieve pregnancy and were supplemented with
low-doses of GH in a subsequent cycle using the same gonadotropin dose and protocol. Our
primary endpoint was the clinical pregnancy rate (CPR), considering secondary endpoints the
number of retrieved oocytes, embryos, embryo quality and the proportion of cycles with
embryo transfer.
Controlled ovarian hyperstimulation will be performed using a GnRH agonist long protocol
from day 21-23 of the menstrual cycle at a dose of 1 mg/ day, using the same schedule and
dose as in the previous cycle, so that the only difference between them is the GH
supplementation.
After confirming pituitary inhibition, the dose of GnRH agonist will be decreased to 0.5
mg/day, and COH will begin with gonadotropins at a dose of 300 UI, subsequently adjusting
according to clinical response. Human chorionic gonadotropin (hCG) will be administered when
follicles reached > 17 mm in diameter. A dose of 0.5 IU of GH will be administered daily
from the first day of the agonist until the day of hCG administration. Oocyte retrieval will
be performed 36 hours after hCG administration by ultrasound-guided follicle aspiration.
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