Infertility Clinical Trial
Official title:
Comparative Study Between Minidose Long Protocol and Microdose Flare Protocol in Controlled Ovarian Hyperstimulation for Poor Responders in ICSI Cycles
Verified date | January 2015 |
Source | Kasr El Aini Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | Egypt: Ministry of Higher Education |
Study type | Interventional |
Objective: To compare two stimulation protocols, the minidose long protocol and the
microdose flare protocol designed for low responders undergoing ICSI.
Design: Randomized prospective study. Setting: University hospital IVF unit. Patients: 60
poor responder patients coming for IVF center for ICSI. Interventions: Minidose long
protocol in which half the dose of agonist was administered from the mid luteal phase until
the day of HCG administration was compared with microdose flare protocol in which half the
dose of GnRH was administered from the second day of the cycle until the day of HCG
administration. Both groups received Gn stimulation from the second day of the cycle
(300-450 IU).
Main outcome measures: Number of oocytes retrieved.
Status | Completed |
Enrollment | 60 |
Est. completion date | December 2011 |
Est. primary completion date | December 2011 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 35 Years to 42 Years |
Eligibility |
Inclusion Criteria: - Age > 35 years - Day 3 serum FSH level > 10m IU/ml - Number of antral follicles measuring 4-8mm during the early phase < 6 - Small ovarian volume - AMH < 1 - Prior poor ovarian response to COH (oocytes < 5) Exclusion Criteria: - Polycystic ovarian syndrome patients - Patients with Endometriosis - Normal responders to ovulation induction - Patients having ovarian cyst - Patients receiving ovulation induction in the preceding cycle |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Kasr El Aini Hospital |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of Oocytes Retrieved | 12 months | No |
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