Infertility Clinical Trial
Official title:
Effects of Granulocyte - Macrophage Colony - Stimulating Factor (GM-CSF) Supplementation in Embryo Culture in Patients With Repeated Implantation Failure
The purpose of this study was to investigate the potential effects of Granulocyte-Macrophage Stimulating-Colony Factor (GM-CSF) supplementation in embryo culture for patients with repeated implantation failure (RIF)
60 patients with repeated implantation failure were involved.
RIF was defined as patients failed to conceive (beta-hCG < 5 mIU/mL) after at least 03
embryo transfers (fresh and frozen) with 06 top quality embryos or more.
Ovarian stimulation was performed using GnRH antagonist protocol. All matured oocytes were
inseminated by ICSI. Injected oocytes were cultured in medium supplemented with 2ng/ml of
GM-CSF (Embryogen, Origio) until day of transfer. Embryo evaluation was performed at fixed
time points of 18 and 44 hour after fertilization. Embryo transfer was performed 2 days
after ovum retrieval.
Luteal-phase support was provided using progesterone gel (Crinone 8% 90 mg, twice a day;
Merck Serono) and estradiol per os (Valiera 2mg, twice a day; Laboratorios Recalcine). Serum
hCG was measured 16 days after oocyte retrieval, and if positive, an ultrasound scan was
performed at gestational weeks 7 and 12.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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