Infertility Clinical Trial
Official title:
Salpingectomy Versus Aspiration of Hydrosalpingeal Fluid Prior to IVF-ET.A Randomized Controlled Trial
The aim of this randomized controlled trial is to compare the efficacy of ultrasound guided aspiration of hydrosalpingeal fluid with salpingectomy in the management patients with ultrasound visible hydrosalpinges undergoing IVF-ET.
The adverse impact of hydrosalpinx on in vitro fertilisation embryo transfer (IVF-ET)
outcomes has been confirmed by several retrospective and prospective studies .
Cochrane review of prospective randomised trials of laparoscopic salpingectomy confirmed the
beneficial effect of laparoscopic salpingectomy on IVF-ET outcomes in patients with
hydrosalpinges.
Surgery is not usually safe especially in patients with extensive adhesions, morbid obesity
or previous multiple laparotomies. Furthermore, many infertile couples refuse to undergo
bilateral salpingectomy or proximal tubal occlusion because these procedures remove any hope
of spontaneous pregnancy. Other less invasive options for patients with hydrosalpinges as
ultrasound-guided aspiration of hydrosalpingeal fluid, antibiotics (alone or combined with
aspiration) and hysteroscopic occlusion of fallopian tube were studied in order to find an
alternative to salpingectomy . Although these methods are simple and getting popular,
current data are inadequate to recommend these treatment options instead of salpingectomy
because most of the supporting evidences for these methods come from small retrospective
studies.
A recent randomized controlled trial revealed that the aspiration of hydrosalpingeal fluid
at the time of oocyte retrieval was associated with improved implantation rate and pregnancy
rates.
The aim of this randomized controlled trial is to compare the efficacy of ultrasound guided
aspiration of hydrosalpingeal fluid with salpingectomy in the management patients with
ultrasound visible hydrosalpinges undergoing IVF-ET
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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