Infertility Clinical Trial
Official title:
GM-CSF Supplemented Medium for IVF Embryo Growth in Patients With Recurrent Implantation Failure
The purpose of this study is to determine whether in Assisted Reproductive Technologies the use of culture medium supplemented with GM-CSF, a growth factor working on stem cells, may improve the embryo implantation in patients experiencing recurrent implantation failure in IVF cycles.
Status | Completed |
Enrollment | 100 |
Est. completion date | December 2015 |
Est. primary completion date | December 2015 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 20 Years to 40 Years |
Eligibility |
Inclusion Criteria: - woman age 40 years old or less, - 3 or more consecutive previous failed IVF cycles with a total of at least 8 good embryos replaced in uterus Exclusion Criteria: - chromosomal defects in the couple, - metabolic diseases (diabetes, etc), - other genetic diseases (thalassemia, cystic fibrosis, etc.) |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Italy | Villa Salaria Fisiopatologia Riproduzione | Rome |
Lead Sponsor | Collaborator |
---|---|
Centre for Endocrinology and Reproductive Medicine, Italy |
Italy,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Pregnancy rate | The number of patients become pregnant after IVF where GM-CSF medium is used, compared with the number of patients become pregnant in the control group | 9 months | No |
Secondary | Implantation rate | number of embryos implanted | 9 months | No |
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