Infertility Clinical Trial
Official title:
Prospective Randomized Trial on GnRH Agonist Triggering Versus hCG Triggering in IVF Stimulation in PCOS Patients
Verified date | February 2021 |
Source | AZ Jan Palfijn Gent |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In this study the investigators compare the traditional way of triggering with a new way in patients with Poly Cystic Ovary Syndrome (PCOS). This to reduce the risque of Ovary Hyper Stimulation Syndrome (OHSS) in In Vitro Fertilization/ IntraCytoplastic Sperm Injection (IVF/ ICSI) treatment. The investigators also compare the number of mature oocytes, embryo's and pregnancy rate.
Status | Completed |
Enrollment | 120 |
Est. completion date | February 2015 |
Est. primary completion date | February 2015 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 38 Years |
Eligibility | Inclusion Criteria: - ICSI patients below 38 years - 1, 2 and 3e IVF cycle - Body Mass Index (BMI) less than 32 - PCOS patients Exclusion Criteria: - endocrinal diseases or problems |
Country | Name | City | State |
---|---|---|---|
Belgium | AZ Jan Palfijn | Gent | Oost-vlaanderen |
Lead Sponsor | Collaborator |
---|---|
AZ Jan Palfijn Gent | Onze Lieve Vrouw Hospital |
Belgium,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | MII oocytes | The number of mature oocytes retrieved after stimulation without creating OHSS | patients will be followed during the stimulation with an average of 10 days | |
Primary | 2 Pro Nuclei (2PN) fertilization | laboratory follow up of the fertilized egg during the first 24h | 24h after ICSI | |
Secondary | implantation rate | The number of pregnancies obtained wich still is the most important issue for the patients | 12 weeks | |
Secondary | OHSS | patient follow up according to subjective complaints and objective measures | one month with oocyte retrieval in the middle |
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