Perifollicular Doppler in Natural Cycle In Vitro Fertilization

Infertility Clinical Trial

Official title:

Perifollicular Doppler in Natural Cycle In Vitro Fertilization

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01668212
• Other study ID #: OVO-11-01
• Status: Completed
• Phase: N/A
• First received: June 19, 2012
• Last updated: June 21, 2013
• Start date: March 2012

Study information

• Verified date: June 2013
• Source: OVO R & D
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: Ethics Review Committee
• Study type: Observational

Clinical Trial Summary

Perifollicular Doppler could reflect the quality of the follicle's vascularization and, consequently, the one of the oocyte that ensues from it. Perifollicuar Doppler is the analysis, in ultrasound, of the blood flow in vessels surrounding the follicle.

The goal of this study is to evaluate if there is a link, in natural cycle In Vitro Fertilization, between the quality of the vascularization and the one of the oocyte, the embryo and the pregnancy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 160
• Est. primary completion date: May 2013
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 18 Years to 38 Years

Eligibility

Inclusion Criteria:

• Patient with a natural In Vitro Fertilization cycle.

• Patient under 38 years old

• Body mass indice under 35

• Ovulatory cycles between 20-35 days

Exclusion Criteria:

• Patient with a stimulation In Vitro Fertilization cycle

• Patient with a naturalIn Vitro Fertilization cycle with egg donor

• Patient with a natural In Vitro Fertilization cycle with freezing embryo

• Smoking patient

• Diabetic patient

• Patient with treatment of antihypertensive drug, anticoagulant, antiplatelet, vasodilator

• Body mass indice over 35

• Patient over 38 years old

• Patient without ovulation or cycle over 35 days

• Percutaneous Epididymal Sperm Aspiration (PESA), Testicular Sperm Extraction (TESE) or micro TESE

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Related Conditions & MeSH terms

• Infertility

Intervention

Procedure:
• Doppler ultrasound
Doppler Ultrasound

Locations

Country	Name	City	State
Canada	Ovo Fertilité	Montréal	Quebec

Sponsors (1)

Lead Sponsor	Collaborator
OVO R & D

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Quality perifollicular doppler and quality of the oocyte	The measurements are done twice; on days of induction and oocyte retrieval. During the blood sample collection on the day of the induction, there is also a measurement of progesterone, estradiol and luteinizing hormone (LH).	2 weeks	No