Infertility Clinical Trial
Official title:
To Evaluate the Effect of Low Dose Aspirin in Increasing the Chance of Pregnancy in Frozen Embryo Transfer Cycles
It has been reported that low-dose aspirin and Heparin would lead to an increased Pregnancy rate in patients undergoing IVF-ET. Low-dose aspirin may improve uterine and ovarian perfusion and that aspirin might enhance endometrial receptivity and ovarian responsiveness as well, which could result in better implantation and pregnancy rates after IVF or ICSI treatment. This study assesses potential effects of low-dose aspirin (100 mg daily) on pregnancy rate following frozen embryo transfer.
In the present randomized double-blind prospective study, the patients will be randomly
assigned to the study and control groups. With the onset of endometrial preparation and
estrogen treatment, the study group will receive 100 mg of oral aspirin and the control
group will be given placebo. When endometrial thickness will be found between 8-14 mm,
therapy with progesterone (100 mg IM daily) will be started and embryo transfer will be
performed 48 to 72 hours later. Doppler ultrasonography also is done to calculate Resistive
Index (RI) and Pulsatility Index (PI), the day after progesterone administration.
βHCG will be assessed 14 days after ET. If a pregnancy will be achieved, the patients in
study and control groups will be instructed to continue the aspirin or placebo through 5
weeks and if the pregnancy test result will be negative, the treatment with aspirin or
placebo will be stopped. The patients will be followed until 20 weeks of gestation and the
results of treatment cycle will be compared in two groups.
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