Infertility Clinical Trial
Official title:
C Terminal Peptide Variants of the Fsh Receptor in Women Involved in an Assisted Reproduction Programm : Mechanistic Approach
Verified date | October 2012 |
Source | University Hospital, Tours |
Contact | n/a |
Is FDA regulated | No |
Health authority | France: Ministry of Health |
Study type | Observational |
Follicle-stimulating hormone (FSH) is used in medically assisted procreation, to induce an
ovarian stimulation in women. However, the FSH dose that has to be injected is quite hard to
adjust, because an excess of exogenous hormone could lead to very severe complications for
patient. This hormone acts on its cognate receptor, the FSHR, present on the granulosa cells
surface, and which regulation involve the intra-cytoplasmic carboxy-terminus domain.
The investigators first aimed to research in the c-terminus part of the receptor the
presence of allelic variants that could explain the variations of response to FSH
stimulation.
The investigators also would want to complete the data already known on a functionally
determinant single nucleotide polymorphism on 680 position in the c-terminus part of the
hFSHR.
Then, the investigators would analyze the entire sequence of the hFSHR of patients
presenting an unusual phenotype in response to FSH treatment, in order to detect a potential
mutation involved in the receptor functionality.
The results of this study could allow us to increase our knowledge on the hFSHR physiology
and functionality, in order to adjust treatment to the genetic profile of patients.
Status | Completed |
Enrollment | 814 |
Est. completion date | April 2011 |
Est. primary completion date | April 2011 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - patients above 18 years, - entering an IVF cycle - informed consent - NHS operative Exclusion Criteria: |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
France | CHRU de Tours | Tours |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Tours |
France,
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