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NCT01501292 Clinical Trial

Changes in the Distribution of Mitochondria During Oocyte Maturation

Infertility Clinical Trial

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT01501292
Other study ID # 0095-11-HYMC
Secondary ID
Status Not yet recruiting
Phase N/A
First received December 13, 2011
Last updated December 26, 2011
Start date January 2012
Est. completion date April 2012

Study information
Verified date December 2011
Source Hillel Yaffe Medical Center
Contact Adrian Ellenbogen, MD
Phone 972-50-6246722
Email ellenbogen@hy.health.gov.il
Is FDA regulated No
Health authority Israel: Ministry of Health
Study type Observational

Clinical Trial Summary

Cytoplasmatic maturation is an important event in the general maturation of of the oocyte. Mitochondria is one of the major organelles involved in the process of cytoplasmatic maturation. The aim of this study is to investigate the presence and distribution of the mitochondria in the cytoplasma of immature oocytes that are retrieved in the routine in-vitro maturation cycle with intracytoplasmatic sperm injection (ICSI). These oocytes will not undergo ICSI because of their immaturity. Usually, they are discarded. In addition to these immature oocytes the investigators shall also investigate the mitochondria in mature oocytes that underwent ICSI but did not become fertilized and are discarded.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 20
Est. completion date April 2012
Est. primary completion date April 2012
Accepts healthy volunteers No
Gender Female
Age group 18 Years to 44 Years
Eligibility Inclusion Criteria:

- Infertile patients needing IVF treatment

Exclusion Criteria:

- Patients not requiring the ICSI procedure

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Intervention

Other:
• Fixation and staining
Fixation and staining by MitiTracker Green FM
• Observation by laser microscopy
Observation with Laser scanning confocal microscopy

Locations
Country Name City State
Israel Hillel Yaffe Medical Center Hadera

Sponsors (1)
Lead Sponsor Collaborator
Hillel Yaffe Medical Center

Country where clinical trial is conducted

Israel, 

Outcome
Type Measure Description Time frame Safety issue
Primary The patterns of mitochondrial distribution within the cytoplasma of oocytes during nuclear maturation Identification the different patterns of mitochondrial distribution in correlation with the 3 stages nuclear maturation in human oocytes Three months No
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