Infertility Clinical Trial
Official title:
Timing of Estrogen Support During the Luteal Phase of IVF / Intracytoplasmic Sperm Injection Cycle: a Randomized Controlled Trial
To test the hypothesis that adding estradiol (E2) to progesterone supplementation later in the luteal phase of in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles, rather than earlier in the luteal phase, improves clinical pregnancy rates (PRs).
Status | Completed |
Enrollment | 301 |
Est. completion date | November 2008 |
Est. primary completion date | November 2008 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | N/A to 40 Years |
Eligibility |
Inclusion Criteria: - All patients on long GnRH agonist protocol with controlled ovarian hyperstimulation who were seen in our IVF clinic between February and November 2008, and who have E2 levels on the day of hCG administration >2500 pg/dl Exclusion Criteria: - Presence of azoospermia requiring testicular sperm extraction procedure - endometriosis greater than stage II - unilateral oophorectomy, polycystic ovarian syndrome (PCOS) - secondary infertility - age greater than 40 yrs and a basal follicle stimulating hormone (FSH) level higher than 12 mIU/ml were exclusion criteria |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Turkey | Zekai Tahir Burak Maternity and Teaching Hospital | Ankara |
Lead Sponsor | Collaborator |
---|---|
Zekai Tahir Burak Women's Health Research and Education Hospital |
Turkey,
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* Note: There are 30 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Clinical pregnancy rate | Clinical pregnancies were detected with the confirmation of positive fetal cardiac activities by transvaginal sonography in the sixth gestational week. | sixth gestational week. | No |
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