Infertility Clinical Trial
Official title:
A Prospective, Randomized, Double Blind, Study on the Clinical Efficacy Myo-inositol Versus D-chiro-inositol in Women Undergoing in Vitro Fertilization Embryo Transfer.
Controlled ovarian hyperstimulation with gonadotropins is an integral part of the various
stimulation protocols for patients undergoing in-vitro fertilization (IVF) and other
Assisted Reproductive Technologies (ART) such as intracytoplasmic sperm injection (ICSI).
The hormonal control of multiple follicular growth and maturation is a critical part of ART
procedures since it maximizes the yield of embryos to be transferred, thus increasing the
cumulative pregnancy rate.
Recent studies have shown the efficacy of myo-inositol (MI) supplementation as a simple and
highly effective treatment in order to improve oocyte quality in patients undergoing IVF.
Indeed, it was previously shown that MI follicular fluid (FF) concentration is a reliable
predictor of oocyte quality. High MI concentration in the FF directly correlates with high
oocyte and embryo quality.
Another stereoisomer of Inositol was successfully used into clinical practice
D-chiro-inositol (DCI). In particular, DCI supplementation was used to restore ovulation in
hyperglycemic PCOS patients.
In the present study we aim to compare MI versus DCI supplementation on oocyte quality of
women undergoing IVF-ET
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator)
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