Infertility Clinical Trial
Official title:
Does Endometrial Injury in the Non-Transfer Cycle Improve the IVF-ET Outcome in the Subsequent Cycle in Patients With Previous Failed IVF Cycles: A Randomized Control Trial
Implantation of the human embryo is the limiting factor in the success of invitro-fertilization and embryo transfer(IVF-ET).We wanted to find out whether creating a local injury to the endometrium in the non-transfer cycle would improve the IVF-ET outcome in the subsequent cycle.We believe that the injury created causes release of substances which help in implantation.
Study Design and Subjects: This is a randomized control study designed to evaluate the effect
of local injury to the endometrium in non-transfer cycle in patients with previous failed
IVF.
Patients will be randomly allotted to control and intervention group The patients in the
intervention group Pipelle endometrial sampling 7-10th day and 24-26th day in the cycle prior
to IVF transfer cycle.
Outcome Measures: Clinical pregnancy rate,implantation rate and ongoing pregnancy rate.
SAMPLE SIZE: 100 PATIENTS (50 in each group).
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