Infertility Clinical Trial
Official title:
The Flexible GnRH Antagonist Protocol Provides Better Results (IVF Outcomes) Than Flare up GnRH Agonist Protocol in Poor Responders
Verified date | January 2009 |
Source | Eugonia |
Contact | n/a |
Is FDA regulated | No |
Health authority | Greece: National Organization of Medicines |
Study type | Interventional |
The purpose of this study is to compare ovulation induction using a flexible GnRH antagonist protocol and flare up GnRH agonist protocol in IVF patients with poor response to ovarian stimulation. Our hypothesis is that the antagonist protocol provides better IVF outcomes compared to the flare up protocol in this group of patients.
Status | Completed |
Enrollment | 270 |
Est. completion date | July 2006 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 50 Years |
Eligibility |
Inclusion Criteria: - regular menstrual cycle - 1 or more failed IVF attempts with poor response - 5 or fewer oocytes retrieved - FSH>12 IU/l on day 3 Exclusion Criteria: - PCOS - Normal responders |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Greece | Eugonia | Athens |
Lead Sponsor | Collaborator |
---|---|
Eugonia |
Greece,
Tarlatzis BC, Zepiridis L, Grimbizis G, Bontis J. Clinical management of low ovarian response to stimulation for IVF: a systematic review. Hum Reprod Update. 2003 Jan-Feb;9(1):61-76. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Ongoing pregnancy rate per embryo transfer | |||
Secondary | Duration of ovarian stimulation, total rFSH used, estradiol, LH and progesterone concentration on hCG day. | |||
Secondary | Number of mature oocytes retrieved. | |||
Secondary | Number of fertilised oocytes. |
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