Infertility Clinical Trial
Official title:
Evaluation of the Role of Factor V Leiden Mutation in Implantation Failure
Verified date | August 2011 |
Source | University of Pennsylvania |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Observational |
The purpose of this study is to determine whether inherited thrombophilias (tendency toward blood clotting) increase the risk of failure of the embryo to implant in IVF. The specific condition to be studied is the presence or absence of the Leiden mutation of the Factor V gene.
Status | Completed |
Enrollment | 399 |
Est. completion date | August 2005 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Women undergoing in-vitro fertilization with successful ovarian hyperstimulation, oocyte retrieval, and fertilization - Transfer of at least 2 fresh embryos of Grade 2 (preembryo with blastomeres of equal size and <=10% cytoplasmic fragmentation) or better Exclusion Criteria: - Infertility due to uterine anatomic defect - Current use of anticoagulant medication, such as heparin or aspirin - Known presence of any other condition associated with increased risk of thrombosis |
Observational Model: Cohort, Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
United States | University of Pennsylvania Reproductive Research Unit | Philadelphia | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
University of Pennsylvania |
United States,
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