Infertility Clinical Trial
Official title:
Effects of Hormonal Infertility Treatment on Cognition in Pre-Menopausal Women
The purpose of this study is to examine the effects of marked alterations in ovarian steroid hormones on cognitive functions in women. Sex hormones and stress hormones of women awaiting or undergoing in-vitro fertilization (IVF) will be compared with levels of women adopting children and women on oral contraceptives.
Much of our understanding of the effects of ovarian steroid hormones on cognitive
functioning comes from studies of changes in cognitive function associated with hormone
replacement therapy (HRT) in post-menopausal women and changes in menstrual cycle phase in
premenopausal women. If fluctuations in ovarian sex steroid hormone levels across the normal
physiological range affect cognitive functions in women, then marked alterations in hormone
levels should have a notable effect on cognitive function.
Hormonal in-vitro fertilization (IVF) treatments for female infertility result in dramatic
fluctuations in estrogen levels. Women awaiting infertility treatment report negative
emotions, depressed mood, declines in memory and concentration, and higher levels of
reported stress compared to women who have never experienced infertility.
Four groups of twenty women each will be recruited for this observational study:
- Group 1 - IVF treatment with GnRH-a alone
- Group 2 - IVF treatment with GnRH-a plus sex steroid stimulating hormones
- Group 3 - ADPT control (women in the process of adopting children)
- Group 4 - OC (oral contraceptives) control
All groups will receive a cognitive/affect assessment twice, with a 3-week interval between
assessments. Blood and salivary samples will be taken on the two test days to measure
ovarian sex steroid hormone levels and stress hormone levels. Salivary samples will also be
taken on a third day in between the two test days. Heart Period Variability (HPV), a measure
of cardiac functioning, will be measured using electrocardiogram (ECG).
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