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Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology

Infertility Clinical Trial

Official title:
Effect of Myo-Inositol- Based Co-treatment on Oocyte Quality in Women With Polycystic Ovarian Syndrome Undergoing Assisted Reproductive Technology

Clinical Trial Summary

This is a prospective comparative randomized controlled study investigating the effect of Myo-Inositol-based co-treatment on oocyte quality measures in women with PCOS.

Clinical Trial Description

Polycystic Ovary Syndrome is the most common cause of chronic anovulation in women. Women with PCOS undergoing IVF are at an increased risk for developing both multiple gestation and ovarian hyperstimulation syndrome (OHSS). Since insulin resistance and hyperinsulinemia have been implicated in the pathophysiology of the disorder, the administration of metformin before or during an IVF cycle has been practiced for years in an attempt to improve follicular parameters necessary for reproductive success. Recently, a growing body of evidence has implicated alternative insulin sensitizing drugs, namely Myo-Inositol, in improving various manifestations of the disorder in this women population. Little has been done to evaluate the effect of Myo-Inositol co-treatment on the reproductive performance of PCOS women undergoing Assisted Reproductive Technologies (ART). In this prospective comparative randomized controlled study, women will be randomized into two groups: Women in the control group will receive folic acid daily. Women in the study group will receive Myo-Inositol, in combination with alpha- lipoic acid and cysteine, per day plus folic acid supplemented daily along with ovarian stimulation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03177122
Study type Interventional
Source American University of Beirut Medical Center
Contact Johnny Awwad, MD
Phone 009611350000
Email jawwad@aub.edu.lb
Status Recruiting
Phase Phase 4
Start date March 1, 2017
Completion date December 31, 2023
View Details
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