Infertility, Female Clinical Trial
Official title:
Comparison of Reproductive Outcomes After Progestin-primed Ovarian Stimulation With Dydrogesterone Versus Cetrorelix to Inhibit Spontaneous Ovulation in Oocyte Donation
Verified date | October 2022 |
Source | Clinica de la Mujer Medicina Reproductiva, Chile |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Prospective controlled study to assess the reproductive outcomes of OD recipients in which the donors were subjected to the DYG protocol (20mg/day) compared with those subjected to the short protocol with cetrorelix (0.25 mg/day) from Day 7 or since a leading follicle reached 14 mm. The OD cycles were triggered with triptoreline acetate and the trigger criterion was ≥3 follicles of diameter >18mm.
Status | Completed |
Enrollment | 202 |
Est. completion date | December 31, 2021 |
Est. primary completion date | December 31, 2021 |
Accepts healthy volunteers | |
Gender | Female |
Age group | 21 Years to 30 Years |
Eligibility | Inclusion Criteria: - Oocyte donors between 21 and 30 years old, with regular menstrual cycles (24-35 d) and a body mass index (BMI) between 18 and 28 kg/m2 without any relevant personal or family history Exclusion Criteria: - AMH less than 3 ng/dL - A positive screening for sexually transmitted diseases |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Clinica de la Mujer Medicina Reproductiva, Chile |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Live Birth Rate per transfer | 40 weeks after ET | ||
Primary | Clinical pregnancy per transfer | 12 weeks after ET | ||
Primary | Miscarriage rate | 12 weeks after ET | ||
Secondary | Number of oocytes retrieved | at time of oocyte retrieval | ||
Secondary | Number of mature oocytes | 1 day after IVF | ||
Secondary | Number of fertilized oocytes | 1 day after IVF | ||
Secondary | Number of blastocists | 5-6 days after OPU |
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