Clinical Trials Logo
  1. Home
  2. Infertility, Female
  3. NCT04185623
  4. Details
NCT04185623 Clinical Trial

Time Lag for Oocyte Denudation: A Better Choice for ICSI Outcome?!

Infertility, Female Clinical Trial

Official title:
Time Lag for Oocyte Denudation:Is it a Better Choice for ICSI Outcome?!

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04185623
Other study ID # Hawaa-8
Secondary ID
Status Completed
Phase
First received
Last updated
Start date June 1, 2019
Est. completion date December 1, 2020

Study information
Verified date September 2022
Source Benha University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study aiming to investigate if difference in the timing of cumulus removal post retrieval would have any critical impact on fertilization and embryonic development.

Description:

Patients under 37 year old who were treated with controlled ovarian stimulation for ICSI were randomly divided into 2 groups; Group A: Oocytes were denudated immediately after oocyte retrieval , Group B: Oocytes were denudated 2 hours after retrieval and both groups were microinjected at 4 hours from ovum pickup. Microinjection was performed on all matured oocytes only and they were cultured to blastocyst stage.The rates of maturation, fertilization, good quality blastulation, chemical pregnancy and clinical pregnancy were analysed and compared between the two groups.

Recruitment information / eligibility
Status Completed
Enrollment 300
Est. completion date December 1, 2020
Est. primary completion date October 1, 2020
Accepts healthy volunteers No
Gender Female
Age group 24 Years to 37 Years
Eligibility Inclusion Criteria: - Women 24-37 years old - With good ovarian reserve - Induction using Long agonist protocol - unexplained infertility Exclusion Criteria: - severe male factor - Testicular samples for ICSI - poor ovarian reserve - no of oocytes collected less than 4

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• denudation time lag
The time between ovum pickup and denudation of oocyte

Locations
Country Name City State
Egypt Hawaa Fertility Center Banha Qalyubiya

Sponsors (2)
Lead Sponsor Collaborator
Ahmed Saad Hawaa Fertility Center

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Day 5, good quality blastocyst Assessment were done according to gardener classification 120 hour post ovum pickup
Secondary clinical pregnancy Assessment was done by observation of a gestational sac at 6 wks 6 weeks from the last normal menstrual period
See also
  Status Clinical Trial Phase
Recruiting NCT05969574 - Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?
Recruiting NCT05358483 - PROspective Study of Mothers' and Infants' Social and Epidemiologic Determinants of Health
Recruiting NCT05969795 - Comparison of Live Birth Rate in Natural Cycle Single Euploid FET Versus Without Luteal Phase Support Phase 1
Recruiting NCT06051201 - Innovation for Small-scale Experiments: ReceptIVFity Test N/A
Completed NCT03177538 - Corifollitropin Alfa Combined With Menotropin Versus Follitropin and Lutropin Alfa in Expected Suboptimal Responders Phase 4
Completed NCT03638856 - Comparing Effectiveness of Oral Misoprostal for Cervical Priming in Hysteroscopy N/A
Completed NCT04052464 - The Study of the Implantation Window From Endometrial Biopsy With Gene Expression Methods
Withdrawn NCT04753736 - Immunophenotypage of RIF and RM Patients and Intrauterine Administration of PBMC N/A
Completed NCT03349905 - Deferred Versus Fresh Embryo Transfers N/A
Completed NCT05076981 - Progesterone Levels During Ovulation and Luteal Phase
Completed NCT04096027 - Cabergoline Before or After Oocyte Collection for Follicular Resolution Phase 4
Recruiting NCT05980091 - Optimal Timing of Euploid Day 6 Blastocyst Transfer in Frozen HRT Cycles, Day 6 or Day 7 of Progesterone Administration. Phase 1
Terminated NCT01933633 - Improved Fertility After Exercise in Overweight/Obese Women N/A
Terminated NCT01202643 - Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF Phase 1/Phase 2
Completed NCT01202656 - Effect of Colony Stimulating Factor on Implantation and Pregnancy Rates Following IVF (in Vitro Fertilization) Phase 1/Phase 2
Completed NCT01408615 - A Post Marketing Observational Study of the Safety and Efficacy of Elonva (Corifollitropin Alfa) in General Practice (P08165)
Enrolling by invitation NCT05698550 - The Role of Erzhi Tiangui Formula in Expected POR Women Undergoing IVF-ET Phase 3
Not yet recruiting NCT03910582 - Personalized FET in RIF Patients With Displaced Dating N/A
Completed NCT05440019 - Evaluation of the Safety and Usability of the M3T Fertigo System and Its Calibration
Completed NCT05130125 - Retrospective Cohort Observational Study to Evaluate the Effectiveness and Safety of Fresh or Frozen Embryo Transfer