Infertility, Female Clinical Trial
— PRPOfficial title:
Investigating Improvement of Ovarian Function Following Autologous PRP Intra-ovarian Infusion in Perimenopausal Women
Autologous PRP intra ovarian infusion may improve ovarian response and women's hormonal profile and may promote folliculogenesis in perimenopausal women.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | July 30, 2025 |
Est. primary completion date | January 30, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 40 Years to 50 Years |
Eligibility | Inclusion Criteria: - Women =40 years of age, presenting with cycle irregularities while fulfilling at least one of the respective two criteria: more than seven days difference in menstrual cycle duration between two consecutive cycles OR, presence of a menstrual cycle duration over sixty days and progressive elevation of FSH levels. - Discontinuation of any complementary/adjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment. - Willing to comply with study requirements Exclusion Criteria: - Any pathological disorder related to reproductive system anatomy - Amenorrhea - Endometriosis - Adenomyosis - Fibroids and adhesions - Infections in reproductive system - Current or previous diagnosis of cancer in reproductive system - History of familiar cancer in reproductive system - Severe male factor infertility - Prior referral for PGT - Ovarian inaccessibility - Previous POI diagnosis -Endocrinological disorders (Hypothalamus- - Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome) - BMI>30 kg/m2 or BMI<18.5 kg/m2 - Systematic autoimmune disorders |
Country | Name | City | State |
---|---|---|---|
Greece | Genesis AC | Athens |
Lead Sponsor | Collaborator |
---|---|
Genesis Athens Clinic | National and Kapodistrian University of Athens |
Greece,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Restoration of menstrual cycle regularity | Regular Menstrual cycle | Three months | |
Primary | Serum FSH levels | Serum FSH levels evaluated monthly for three consecutive months. | Follow-up period of three months entailing monthly evaluation | |
Secondary | Serum AMH levels | Serum AMH levels evaluated monthly for three consecutive months. | Follow-up period of three months entailing monthly evaluation | |
Secondary | Serum LH levels | Serum LH levels evaluated monthly for three consecutive months. | Follow-up period of three months entailing monthly evaluation | |
Secondary | Serum Estradiol levels | Serum etsradiol levels evaluated monthly for three consecutive months. | Follow-up period of three months entailing monthly evaluation | |
Secondary | Serum Progesteron levels | Serum progesterone levels evaluated monthly for three consecutive months. | Follow-up period of three months entailing monthly evaluation | |
Secondary | Antral Follicle Count | AFC evaluated monthly, on day 2 of the menstrual cycle, for three consecutive months. | Follow-up period of three months entailing monthly evaluation |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05969574 -
Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?
|
||
Recruiting |
NCT05358483 -
PROspective Study of Mothers' and Infants' Social and Epidemiologic Determinants of Health
|
||
Recruiting |
NCT05969795 -
Comparison of Live Birth Rate in Natural Cycle Single Euploid FET Versus Without Luteal Phase Support
|
Phase 1 | |
Recruiting |
NCT06051201 -
Innovation for Small-scale Experiments: ReceptIVFity Test
|
N/A | |
Completed |
NCT03177538 -
Corifollitropin Alfa Combined With Menotropin Versus Follitropin and Lutropin Alfa in Expected Suboptimal Responders
|
Phase 4 | |
Completed |
NCT03638856 -
Comparing Effectiveness of Oral Misoprostal for Cervical Priming in Hysteroscopy
|
N/A | |
Completed |
NCT04052464 -
The Study of the Implantation Window From Endometrial Biopsy With Gene Expression Methods
|
||
Withdrawn |
NCT04753736 -
Immunophenotypage of RIF and RM Patients and Intrauterine Administration of PBMC
|
N/A | |
Completed |
NCT03349905 -
Deferred Versus Fresh Embryo Transfers
|
N/A | |
Completed |
NCT05076981 -
Progesterone Levels During Ovulation and Luteal Phase
|
||
Completed |
NCT04096027 -
Cabergoline Before or After Oocyte Collection for Follicular Resolution
|
Phase 4 | |
Recruiting |
NCT05980091 -
Optimal Timing of Euploid Day 6 Blastocyst Transfer in Frozen HRT Cycles, Day 6 or Day 7 of Progesterone Administration.
|
Phase 1 | |
Terminated |
NCT01933633 -
Improved Fertility After Exercise in Overweight/Obese Women
|
N/A | |
Completed |
NCT01202656 -
Effect of Colony Stimulating Factor on Implantation and Pregnancy Rates Following IVF (in Vitro Fertilization)
|
Phase 1/Phase 2 | |
Terminated |
NCT01202643 -
Effect of Colony Stimulating Factor on Poor Endometrial Development During IVF
|
Phase 1/Phase 2 | |
Completed |
NCT01408615 -
A Post Marketing Observational Study of the Safety and Efficacy of Elonva (Corifollitropin Alfa) in General Practice (P08165)
|
||
Enrolling by invitation |
NCT05698550 -
The Role of Erzhi Tiangui Formula in Expected POR Women Undergoing IVF-ET
|
Phase 3 | |
Not yet recruiting |
NCT03910582 -
Personalized FET in RIF Patients With Displaced Dating
|
N/A | |
Completed |
NCT05440019 -
Evaluation of the Safety and Usability of the M3T Fertigo System and Its Calibration
|
||
Completed |
NCT05130125 -
Retrospective Cohort Observational Study to Evaluate the Effectiveness and Safety of Fresh or Frozen Embryo Transfer
|