Infertility, Female Clinical Trial
Official title:
A Randomized Clinical Trial of Endometrial Histological Dating for Personalized Frozen-thawed Embryo Transfer (pFET) in Patients With Repeated Implantation Failure (RIF) in Natural Cycle
The endometrium becomes receptive as a result of a series of timed hormonal events during the
menstrual cycle. The exposure of the endometrium to progesterone after ovulation initiates
morphological and functional alterations that result in the change from a pre-receptive to a
receptive endometrium. The morphological changes observed on histology for each specific day
after ovulation were described by Noyes and his colleagues in 1950. An endometrial biopsy
that shows a difference of more than 2 days between the histologic dating and actual day
after ovulation is considered to be "out of phase" However, the clinical application of the
Noyes criterion is relatively limited. We have verified the Noyes criterion in natural cycle
in previous study which conducting endometrial biopsies respectively on day 3, 5, 7, 9 and 11
of post-ovulation (PO+3/5/7/9/11)(unpublished data).
The clinical value of the endometrial histological dating in RIF patients in natural cycle is
still to be answered. In this study, we tried to investigate the clinical effects of pFET in
unexplained RIF patients according to the use of classic histologic endometrial dating to
estimate the timing of the window of implantation and to adjust embryo transfer time in
natural cycle.
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