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Clinical Trial Summary

This will be a prospective, randomized (1:1 ratio) clinical trial for non-male factor infertility in advanced maternal age with or without intracytoplasmic sperm injection(ICSI). Qualified 1422 patients are randomized into either of two groups: group A will undergo conventional in-vitro fertilization(IVF)(711 cases), Group B will undergo intracytoplasmic sperm injection (ICSI) (711 cases). All participants will receive the same protocol for ovarian stimulation and standardized luteal phase support.

The target population will be patients with non-male factor infertility aged ≥38years with FSH ≤15. Women with other reasons of infertility (eg. anovulation, endometriosis, and premature ovarian failure) are excluded.

The randomization will take place before controlled ovarian stimulation by a computer randomization system. The accumulated live birth rate , pregnancy complications will be followed up by checking medical records and telephone calls.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03120884
Study type Interventional
Source International Peace Maternity and Child Health Hospital
Contact He-Feng Huang, MD
Phone +86-21-18017310186
Email hefenghuang@126.com
Status Not yet recruiting
Phase N/A
Start date September 1, 2017
Completion date September 1, 2019

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