Infertility, Female Clinical Trial
Official title:
Comparison of IVF Outcome and Endometrium Effect in Infertility Patients Between Diminished and Normal Ovarian Reserve After Melatonin Administration.
Poor sleep quality may lead to increase in oxidative stress and free radicals which in turn may decrease the reproductive function. Many researchers have already proven improvement on reproductive function after antioxidant (melatonin) administration. The investigators wish to study the relationship between unexplained, young poor ovarian responder and oxidative stress.
Poor sleep quality may lead to increase in oxidative stress and free radicals which in turn
may decrease the reproductive function. Many researchers have already proven improvement on
reproductive function after antioxidant (melatonin) administration. The investigators wish to
study the relationship between unexplained, young poor ovarian responder and oxidative
stress.
This is an randomized controlled trial to evaluate the effect of melatonin to improve the
quality of sleep and reduce the oxidative stress. 100 patients will be randomized in to two
groups, the one with melatonin administration for 2 weeks and the other with placebo
administration. Each group will be composed of 2 sub groups, poor responders and normal
responders.
Then the serum and the follicular fluid will be collected at the time of oocyte retrieval and
melatonin concentration oxidative stress marker will be measured.
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