Infertility, Female Clinical Trial
Official title:
Does Telomerase Activity Have an Effect on Infertility in Patients With Endometriosis ? Assessment of Telomerase Activity in Eutopic, Ectopic Endometrial Tissue and Serum
The goal of the study was the detection of telomerase activity in eutopic, ectopic endometrial tissue and in peripheral blood and finding the correlation between the telomerase activity and clinic findings. With these results, confirmation of the hypothesis regarding the endometriosis pathogenesis and endometriosis-related infertility was aimed.
Although distorted pelvic anatomy, impaired peritoneal, humoral and cellular functions,
decreased implantation rate, oocyte and embryo quality, obstructed utero tubal connection
are most researched aspects of endometriosis-related infertility, etiopathogenesis of
endometriosis-related infertility still remains controversial.
Endometrial cell is a unique eukaryotic somatic cell with cyclic telomerase activity.
Hormone-dependent cyclic variation of endometrial telomerase activity was stated in previous
studies. On the other hand telomerase, activity was shown in endometriotic lesions, whereas
this activity lacks in most of the somatic cells.
In this study, assessment of possible relation to increased telomerase activity in infertile
patients with endometriosis was aimed.
Before published studies were assessed telomerase activity in benign and malign
gynecological conditions and in endometriosis tissue, as well. But evaluation of ectopic and
eutopic endometrial tissue and serum telomerase activity in infertile and fertile
endometriosis and healthy control subjects was not performed.
Correlation of telomerase activity and endometriosis-related infertility was aimed in this
study.
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Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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