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Infertility, Female clinical trials

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NCT ID: NCT04454749 Terminated - Infertility, Female Clinical Trials

Endometrial Compaction and Its Influence on Pregnancy Rate in Frozen Embryo Cycle Regimes

Start date: November 9, 2020
Phase:
Study type: Observational

For a pregnancy to occur, an euploid embryo at blastocyst developmental stage, a receptive endometrium and the synchrony of both is crucial. Many studies lately investigated the influence of the endometrial thickness and pattern on the artificial reproductive technology (ART) outcome, however, with conflicting results.

NCT ID: NCT04438759 Completed - Infertility, Female Clinical Trials

Clinical Efficacy of Virtual Reality During Office Hysteroscopy and Endometrial Biopsy in Subfertility

HYSVIR
Start date: September 10, 2020
Phase: N/A
Study type: Interventional

This study is a comparison between the current standard practice of performing a diagnostic hysteroscopy and a relatively recently developed technology that is added to the standard diagnostic hysteroscopy. The aim of the study is to find out whether this newer technology has an advantage for the patient, in the form of anxiety and pain reduction.

NCT ID: NCT04419740 Not yet recruiting - Infertility, Female Clinical Trials

Impact of a Mindfulness Intervention on Infertile Women Undergoing Assisted Reproductive Technique Treatments

EMOT-IVF
Start date: June 1, 2020
Phase: N/A
Study type: Interventional

Infertility and its treatments can have a significant impact on women's psychological health. Anxiety has a negative impact on quality of life during treatment and can lead to withdrawal of care. the investigators would like to test the effectiveness of an application available via the Internet that offers daily exercises such as mindfulness meditation. Women in the "treatment" group will be instructed to practice meditation exercises using the 15-minute daily application during in vitro fertilization treatment until pregnancy testing. Women in the control group will have the standard care of the centre. The investigators will measure the effectiveness of the intervention on anxiety, depression, quality of life and mindfulness aspects. The investigators will also assess the impact on the chances of pregnancy and stress.

NCT ID: NCT04417569 Completed - Infertility Clinical Trials

A Proof of Concept Study of Serum Progesterone Levels for IVF/ICSI Following HCG Trigger for Oocyte Maturation

Start date: February 4, 2021
Phase:
Study type: Observational

This study will determine the rise of progesterone levels after human chorionic gonadotrophin (hCG) trigger in stimulated cycles IVF/ICSI

NCT ID: NCT04416607 Completed - Infertility, Female Clinical Trials

Corifollitropin Alpha and Ovarian Response

Start date: June 15, 2018
Phase: N/A
Study type: Interventional

Objective: To study whether an administration of corifollitropin alpha modifies the follicular cohort, measured by Follicular Output Rate (FORT), compared to human menopausal gonadotropin (HMG), in infertile patients undergoing in vitro fertilisation (IVF). M/M: 306 infertile patients undergoing in vitro fertilisation (IVF). Ovarian stimulation protocol will be performed with a single dose of 100 μg (<60kg) or 150 μg (≥60kg) corifollitropin alpha in group 1 (n=147), and 150-300 IU/day human menopausal gonadotropin (HMG) according to age, antimullerian hormone (AMH) level and antral follicle count (AFC) in group 2 (n=150). Moreover, FORT will be calculated as the ratio of pre-ovulatory follicle (16-22 mm in diameter) count on day of HCG×100/small antral follicle (3-8 mm) count at baseline.

NCT ID: NCT04411212 Recruiting - Infertility,Female Clinical Trials

G-CSF and PRP in Patients With Recurrent Implantation Failure

Start date: May 28, 2020
Phase: Phase 2
Study type: Interventional

The aim of this randomized controlled trial is to determine whether granulocyte colony-stimulating factor and platelet-rich plasma can be used to enhance the IVF-ET outcomes in patients with recurrent implantation failure

NCT ID: NCT04407065 Recruiting - Infertility, Female Clinical Trials

Double Trigger in Patients With Low Number of Oocytes Retrieved Per Number of Preovulatory Follicles

Start date: May 30, 2020
Phase: Phase 2
Study type: Interventional

The aim of this randomized controlled trial is to determine whether co-administration of GnRH agonist and hCG for final oocyte maturation ( 40 and 34 h prior to oocyte retrieval , respectively) can increase the oocytes yield in patients with history of poor oocytes yield, despite normal response to COH, due to low (<50%) number of oocytes retrieved per number of follicles > 14 mm in diameter on day of hCG administration

NCT ID: NCT04407052 Recruiting - Infertility, Female Clinical Trials

Double Trigger in Patients With Low Proportion of Mature Oocytes

Start date: May 30, 2020
Phase: Phase 2
Study type: Interventional

The aim of this randomized controlled trial is to determine whether co-administration of GnRH agonist and hCG for final oocyte maturation ( 40 and 34 h prior to oocyte retrieval , respectively) can increase the number of mature oocytes in patients with history of low proportion of mature oocytes in previous IVF cycle triggered by HCG.

NCT ID: NCT04395755 Completed - COVID-19 Clinical Trials

Impact of COVID-19 on Psychological Status in Case of IVF Interrupted or Postponed

Start date: April 1, 2020
Phase:
Study type: Observational

Infertility is a severely distressing experience for many couples. Depression and anxiety are psychological disorders associated with infertility, and they may worsen during infertility treatments. This study times to understand the changes in the psychological status of infertile patients who had in vitro fertilization (IVF) treatment interrupted or postponed because of the COVID-19 pandemic.

NCT ID: NCT04390308 Not yet recruiting - Infertility, Female Clinical Trials

Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?

Start date: November 23, 2023
Phase:
Study type: Observational

Premature ovarian failure (POI) is a loss of normal function before age 40, leading to infertility and hypoestrogenism. About 1% of women younger than 40 years old and 0.1% before 30 are affected. Most patients already had impaired or complete loss of fecundity when diagnosed. Hence, the treatment of POI is particularly tough. Currently, no optimal regimen exists to ameliorate ovarian function.