Infective Endocarditis Clinical Trial
Official title:
Detection of the Most Common Micro Organism of Infective Endocarditis in Assiut University Hospital
Indocarditis is an endogenous infection acquired when organisms entering the blood
stream establish on the heart valves, therefore, any bacteremia can potentially result in
endocarditis.
Infective endocarditis is an uncommon disease that often presents as pyrexia of unknown
origin.
The mortality rate in endocarditis was very high before the antibiotic era, even now a day,
the
mortality rate is around 20%(1).A variety of microorganisms can cause IE; staphylococci and
streptococci account for the majority of cases. Staphylococcal IE is a common cause of
healthcare-associated IE ; streptococcal IE is a common cause of community-acquired IE.
Common bacterial pathogens include Staphylococcus aureus , Viridans group streptococci ,
Enterococcus, Coagulase-negative staphylococci , Streptococcus bovis , other streptococci ,
gram-negative bacteria, HACEK organisms in this category include a number of fastidious
gram-negative bacilli: Haemophilus aphrophilus(subsequently called Aggregatibacter
aphrophilus and Aggregatibacter paraphrophilus); Actinobacillus actinomycetemcomitans
(subsequently called Aggregatibacter actinomycetemcomitans); Cardiobacterium hominis;
Eikenella corrodens; and Kingella kingae , and fungi (1,2). A variable proportion of IE
remain blood culture- negative (1-4). Most clinically significant bacteremias are detected
within 48 hours; common and fastidious pathogens (such as members of the HACEK group) may be
detected within five days of incubation with modern automated blood culture detection
systems. The optimal volume of blood for each blood culture in adults is 20 ml.
Zoonotic agents, such as Coxiella burnetii, Brucella spp., and Bartonella spp. were
frequently detected in North Africa and identified as causes of infective endocarditis (IE)
in Egypt (3,4).Blood culture is the most important investigation for diagnosing infective
endocarditis
andto know the prevalence rate of different bacteria and their antibiotic sensitivity
pattern.Positive blood culture is the cornerstone of microbiological diagnosis of IE; three
sets of blood cultures detect 96 to 98 percent of bacteremia. At least three sets of blood
cultures should be obtained from separate venipuncture sites prior to initiation of
antibiotic therapy. Patients with IE typically have continuous bacteremia; therefore, blood
cultures may be collected at any time and need not necessarily be obtained at the time of
fever or chills.
MATERIAL and METHOD A total of 150 blood cultures were received from 50 clinically diagnosed
cases of bacterial endocarditis .
Blood sample was collected under all aseptic precautions.
n/a
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