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Clinical Trial Summary

Retrospective, regional, multicenter study (including the Annecy-Genevois Hospital Center, the Chambéry Métropole Savoie Hospital Center, and the Grenoble University Hospital Center), comparing a cohort of patients treated with Cefazolin with a cohort of patients treated with Penicillin M


Clinical Trial Description

The use of Cefazolin for the treatment of infective endocarditis caused by Staphylococcus meti - S has become commonplace in France following the stockout of injectable Penicillin M, the reference treatment, which occurred during 2016. There is currently no clinical data to prejudge the efficacy of Cefazolin in the context of high inoculum, such as in the treatment of infective endocarditis. On the other hand, recent data have described a better tolerance profile for Cefazolin than for Penicillin M. The objective of this study is to compare the efficacy and safety of Cefazolin with that of Penicillin M in the management of methicillin-susceptible staphylococcal endocarditis, through the analysis of two retrospective cohorts. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05474118
Study type Observational
Source Centre Hospitalier Annecy Genevois
Contact
Status Completed
Phase
Start date February 5, 2020
Completion date March 31, 2022

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