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N-ACetylcysteine to Reduce Infection and Mortality for Alcoholic Hepatitis — NACAH  

Infection Clinical Trial

Official title:
The Mechanism of Action of N-acetylcysteine for Reducing the Risk of Infection in Alcoholic Hepatitis

Clinical Trial Summary

Recent data have suggested that monocyte oxidative burst defect is associated with the development of infection in patients with severe alcoholic hepatitis. One report found reduced 28 day mortality in patients treated with N-acetylcysteine combined with prednisolone when compared to prednisolone alone. The current study seeks to reveal whether the mechanism by which NAC reduces susceptibility to infection is through improvement of phagocyte oxidative burst.

Clinical Trial Description

Randomised controlled trial, open label. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03069300
Study type Interventional
Source Imperial College London
Contact Nikhil Vergis, PhD
Email nvergis@ic.ac.uk
Status Recruiting
Phase Phase 3
Start date October 1, 2015
Completion date June 1, 2025
View Details
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