Infection Clinical Trial
— EC-MOTION
The objective of the study is to investigate the exposure difference between antibiotic
studied patients in intensive care with Extracorporeal Membrane Oxygenation and patients
without Extracorporeal Membrane Oxygenation.
The exhibition is evaluated by population pharmacokinetic modeling.
| Status | Recruiting |
| Enrollment | 60 |
| Est. completion date | July 2019 |
| Est. primary completion date | January 2019 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - Age over 18 years - Hospitalisation in intensive care - Treatment with ECMO or without ECMO - Introducing sepsis treated with an anti-infective molecule studied (piperacillin) for less than 48 hours - With an arterial catheter - Patient Information or their next of kin according to the patients status. Exclusion Criteria: - Pregnancy - Major person under legal protection (backup justice, trusteeship, quardianship), person deprived of liberty |
Observational Model: Case Control, Time Perspective: Prospective
| Country | Name | City | State |
|---|---|---|---|
| France | CHU Rennes | Rennes |
| Lead Sponsor | Collaborator |
|---|---|
| Rennes University Hospital |
France,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Measure exposure to piperacillin | evaluated by population pharmacokinetic modeling and is defined by the time during which the antibiotic concentration is greater than 4 times the critical concentration of the germ to treat | Day 1 | No |
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