Value of PET/CT Imaging in the Diagnosis of Permanent Central Venous Catheters Infection

Infection Clinical Trial

Official title:

Prospective Study on the Usefulness and Diagnostic Value of F-18-FDG PET/CT in the Diagnosis of Permanent Central Venous Catheters Infection

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01434797
• Other study ID #: 89/11
• Status: Completed
• Start date: September 2011
• Est. completion date: March 2020

Study information

• Verified date: March 2020
• Source: University of Lausanne Hospitals
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The study hypothesis is that F-18-FDG PET/CT and microcalorimetry might have a diagnostic value in the detection of permanent central venous catheters (PCVC) infection when conventional means of PCVC infection detection are non-conclusive.

Description:

Permanent central venous catheters are frequently infected and therefore need surgical removal. When a clear diagnostic for infection cannot be defined, catheter removal might be at risk for the patient, for the therapeutic follow-up and in terms of costs. PET/CT and microcalorimetry might help giving conclusive diagnostic of catheter infection.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11
• Est. completion date: March 2020
• Est. primary completion date: November 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• patients with confirmed catheter infection requiring surgical removal

• patients with probable catheter infection requiring surgical removal

• patients with planned removal of uninfected catheter

• =18years old

Exclusion Criteria:

• extreme claustrophobia

• pregnancy and breastfeeding

• severe septicemia

Related Conditions & MeSH terms

• Communicable Diseases
• Infection

Locations

Country	Name	City	State
Switzerland	Centre Hospitalier Universitaire Vaudois, Nuclear Medicine	Lausanne	Vaud

Sponsors (1)

Lead Sponsor	Collaborator
University of Lausanne Hospitals

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Diagnostic value (sensitivity and sensibility, positive/negative predictive value) of F-18-FDG PET/CT imaging in the detection of CVCP infection	To determine the clinical use of PET/CT in the detection of catheter infection by comparing PET/CT imaging results to standard means of catheter infection detection (i.e. clinical signs and hemoculture [positive or negative])	6 months
Secondary	Diagnostic value (sensitivity and sensibility, positive/negative predictive value) of microcalorimetry in the detection of CVCP infection	To determine the clinical use of microcalorimetry in the detection of catheter infection by comparing microcalorimetry results to standard means of catheter infection detection (i.e. clinical signs and hemoculture [positive or negative])	6 months