Infection Clinical Trial
Official title:
Community - Associated Extended-spectrum Beta-lactamases (ESBL)
Verified date | December 2015 |
Source | University of Pittsburgh |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Institutional Review Board |
Study type | Observational |
The purpose of this study is to review patients with E. coli infections at the University of
Pittsburgh Medical Center (UPMC) from September 1, 2006 to August 31, 2007 to determine if
these infections have arisen in the community rather than in hospitals or nursing homes. The
occurrence of such resistant isolates could be devastating if they were associated with
bloodstream infection, such as sometimes accompanies a urinary tract infection, since
antibiotic resistant E. coli is not suspected in isolates coming from the community.
Therefore, the aims of this study are to:
1. Review whether extended-spectrum beta-lactamase (ESBL)-producing organisms (E. coli,
Klebsiella species and Proteus species) are hospital-acquired, healthcare-associated,
or community-associated.
2. Investigate the prevalence of ESBL-positive E. coli in foodstuffs (beef, poultry,
turkey, and pork), as a potential source for ESBL producers in the community.
3. Compare the clonal relationship of the genome and resistance plasmids carried by the
ESBL-producing isolates (healthcare-associated, community-associated, and of animal
origin) and study the associations of ESBL-mediated resistance with resistance to other
classes of antimicrobials.
Status | Completed |
Enrollment | 100 |
Est. completion date | December 2015 |
Est. primary completion date | December 2015 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - All patients with E. coli, Klebsiella species, and Proteus species infections during the time period of the study will be reviewed. A community-associated E. coli isolate will be defined as one which was recovered from a clinical culture from a patient at UPMC who had no established risk factors for infection with an antibiotic resistant organism. Established risk factors are defined as: - Isolation of the organism two or more days after admission for hospitalization OR - History of hospitalization, surgery, dialysis, or residence in a long-term care facility within one year before the culture date OR - The presence of an indwelling catheter or percutaneous medical device (eg, tracheostomy tube, gastrostomy tube, or Foley catheter) at the time of the culture OR - Previous isolation of an antibiotic resistant organism. Exclusion Criteria: |
Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
United States | University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
University of Pittsburgh |
United States,
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