Infection Clinical Trial
Official title:
Prospective Study Comparing the Effectiveness of Zymar and Vigamox for Preoperative Antibiotic Sterilization of the Ocular Surface After Loading Dose
The purpose of this study is to analyze the effect of Zymar and Vigamox on ocular surface bacteria. We believe that Zymar will eradicate more ocular surface bacteria than Vigamox.
Topical antibiotics are frequently used before surgical procedures with the intent of
targetting and reducing the number of bacteria on the surface of the eye. These bacteria
serve as potential sources for post-operative infection. One commonly used method is the
administration of antibiotic drops 3 times: 1 hour prior to surgery at intervals of 5
minutes. Studies in the lab have shown that the preservative benzalkonium chloride 0.005%,
part of the Zymar antibiotic drop preparation, allows the antibiotic to act more effectively
than the antibiotic Vigamox, which does not include this preservative.
Comparison: The effect of Zymar antibiotic eye drops on conjunctival cultures compared to
the effect of Vigamox on conjunctival cultures as measured by conjunctival cultures taken
prior to treatment and then one hour after administration of eye drops 3 times, at 5 minute
intervals.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Prevention
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