Infection Clinical Trial
Official title:
Effect of Fluoride Varnish and CPP-ACP Paste on Oral and Salivary Symptoms of Patients Under Chemotherapy: A Double-blind Clinical Trial
The purpose of this study was to investigate the effect of Fluoride varnish and Casein Phospho-Peptide Amorphous Calcium Phosphate (CPP-ACP) containing paste on oral symptoms and salivary characteristics in patients under chemotherapy.
Chemotherapy as a treatment method of cancers, affects different parts of the oral cavity
such as oral mucosa, teeth and salivary glands caused by salivary glands dysfunction during
chemotherapy.Oral status of patients under chemotherapy will be affected by consumption of
the drugs and their side effects such as reduction of the saliva, dryness of the oral
cavity, changes in bacterial balance, oral mucosa damage, bleeding due to irritation of the
tissues, xerostomia, dental caries, burning sensation, dysgeusia and dysphagia. No effective
preventive protocol has been presented for oral care during chemotherapy.
Patients who were met the inclusion criteria (aged over 12, diagnosed to have cancer by an
oncologists and needed chemotherapy drugs, had at least 20 teeth, had no other pathologic
lesion in their oral cavity, were not treated by radiotherapy and did not have specific
systemic diseases or head and neck cancer) were selected for the study. the participants
were evaluated according to oral and salivary symptoms.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Prevention
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