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NCT ID: NCT01490138 Enrolling by invitation - Fungal Infection Clinical Trials

Investigation of Clinical Relevance of β-D-Glucan Tests in Patients With Invasive Fungal Infection (IFI)

Start date: January 2012
Phase: N/A
Study type: Observational

Invasive fungal infection (IFI) is a disease usually occurred in the patients with compromised immune condition, such as acute leukemia, allogeneic stem cell transplantation or long term immune suppression treatment with the incidence increasing over last decades. Given the introduction of numerous anti-fungal agents and great advance has been made in recent years, IFI is still a dangerous disease with high mortality. Early diagnosis of IFI is still a problem challenging the physicians. Serum tests of β-D-Glucan are introduced to the diagnosis of IFI, which have the advantage of easy application. However, the value of this test in the monitoring of antifungal treatment remains unclear. The investigators perform this study to evaluate the correlation of the serum test results of β-D-Glucan test with the treatment response during the anti-fungal treatment, and hope to see that the results of serial serum tests are good predictive markers for treatment response.

NCT ID: NCT01349738 Enrolling by invitation - Clinical trials for Urinary Tract Infections

Asymptomatic Bacteriuria & Risk of Urinary Tract Infection in Renal Transplants

ASB
Start date: May 2011
Phase: N/A
Study type: Observational

The goal of this research program is to understand the natural history of asymptomatic bacteriuria in the renal transplant patients, to determine if screening for asymptomatic bacteriuria and identification of key host characteristics and virulence factors present on uropathogenic bacteria identifies a sub-population of patients with asymptomatic bacteriuria that are at risk to develop symptomatic urinary tract infection. Ultimately, the knowledge obtained from this study will prevent inappropriate antibiotic use and may identify whether certain bacterial isolates predispose to renal allograft injury. We will test the hypothesis that (i) asymptomatic bacteriuria is common in the renal allograft recipient and (ii) that symptomatic urinary tract infection and renal allograft dysfunction do not occur unless key host susceptibility factors and uropathogenic bacterial virulence factors are present.

NCT ID: NCT01231737 Enrolling by invitation - Clinical trials for Urinary Tract Infection

Efficacy of Two Prophylactic Schedules (Prulifloxacin Versus Phosphomycin)

Start date: November 2010
Phase: Phase 2
Study type: Interventional

Epidemiological studies showed that 20-30% of patients with uncomplicated urinary tract infections risked recurrent infection. Urinary tract infection causes marked discomfort for the patient, has a negative impact upon quality of life, and is associated with high social and health costs in terms of specialist appointments, laboratory and instrumental tests and prescriptions . Although diverse cycles of antibiotic therapy and prophylaxis have been proposed, doubts persist about the most efficacious pharmacological agents, duration of prophylaxis , the incidence of adverse effects and relapse when antibiotic therapy is suspended. Aims of the study: 1. To compare the efficacy of two prophylactic schedules (Prulifloxacin vs Phosphomycin): - in reducing the number of urinary tract infection episodes during prophylaxis - in reducing the number of urinary tract infection episodes after prophylaxis - in improving the patient's quality of life . 2. To assess : - Tolerability of antibiotic prophylaxis - The incidence of resistance to antibiotic therapy

NCT ID: NCT01194115 Enrolling by invitation - Clinical trials for Surgical Site Infection in Obese Women Undergoing C-section

Use of 48 Hour Course of Antibiotics to Prevent Surgical Site Infection in Obese Patients Undergoing Cesarean Delivery

SSI
Start date: September 2010
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate if preoperative antibiotics, followed by 48 hour course of broad spectrum antibiotics prevents wound infection complications in patients that are obese who undergo cesarean section. Standard antibiotic prophylaxis in all weight women undergoing cesarean section is cefazolin prior to skin incision. It is the hypothesis that a prolonged, 48 hour course of broad spectrum antibiotics that are suited to prevent growth of normal vaginal flora will decrease the rate of surgical site infection in obese patients that are at a greatly increased risk of postoperative infections complications.

NCT ID: NCT01153191 Enrolling by invitation - Infections Clinical Trials

Effectiveness for Interventions to Minimize Surgical Site Infections

Start date: August 2010
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate two different simple and inexpensive extra treatments during colorectal surgeries to see if this will reduce the rate of post operative infections

NCT ID: NCT01082770 Enrolling by invitation - Clinical trials for Central Line Infection

Randomised Controlled Trial of Needle Free Access Devices in Preventing Hemodialysis Blood Stream Infection

TEGO
Start date: March 2010
Phase: Phase 4
Study type: Interventional

This study will be a randomised controlled trial examining whether a new type of needle free access device(TEGO) is associated with less episodes of infection of dialysis lines, when compared to the current gold standard. The investigators hypothesise that there will be less handling of the dialysis line by nursing staff and thus this will lead to lower rates of infection. The investigators will also assess whether these access devices lead to alterations in catheter blood flow rates when compared to the current gold standard.

NCT ID: NCT00964093 Enrolling by invitation - Clinical trials for Central Line Bloodstream Infections

The Effectiveness of Silver Alginate (Algidex) Patch in the Prevention of Central Line Infections in Very Low Birth Weight Infants

Start date: March 2009
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether silver alginate (Algidex) patch is effective in the prevention of central line infections in very low birth weight infants.

NCT ID: NCT00900653 Enrolling by invitation - Clinical trials for Urinary Tract Infections

Low Dose Estriol With Lactobacilli Treatment for Preventing Recurrent Urinary Tract Infection in Postmenopausal Women

Start date: May 2009
Phase: Phase 4
Study type: Interventional

Recurrent urinary tract infections (UTI) are a problem for postmenopausal women. The aim of this trial is to evaluate the effectiveness of lactobacilli in combination with low dose estriol for preventing recurrent urinary tract infections in postmenopausal women.