VentFirst Pilot: Ventilating Preterm Infants During Delayed Cord Clamping

Status Completed

Clinical Trial Summary

Delayed clamping of the umbilical cord (DCC) has been shown to have some benefits for preterm infants. Initiation of breathing before cord clamping is also thought to be beneficial. Since some preterm infants do not breathe well on their own immediately after birth, assisting ventilation during delayed cord clamping might have additional benefit beyond DCC alone. "VentFirst Pilot" will assess feasibility and safety of assisting ventilation of preterm infants during 90 seconds of DCC which is essential before proceeding to a randomized clinical trial.

Clinical Trial Description

Mothers expected to deliver an infant at 24-32 completed weeks' gestation will be approached for consent. When the infant is delivered, members of the neonatology team will be at the mother's side and will provide initial steps of resuscitation (position, suction, stimulate) per guidelines of the Neonatology Resuscitation Program (NRP). At 30 seconds after birth, the infant will receive continuous positive airway pressure (CPAP) if breathing well, or positive pressure ventilation (PPV) if not breathing well. At 90 seconds, the umbilical cord will be cut and the remainder of the resuscitation and stabilization will be carried out in the usual location. ;

Study Design

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Infant, Premature, Diseases

Clinical Trial Details

NCT number	NCT02391389
Study type	Interventional
Source	University of Virginia
Contact
Status	Completed
Phase	N/A
Start date	September 2014
Completion date	June 2015

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05030337` - Optimising Ventilation in Preterms With Closed-loop Oxygen Control	N/A
Completed	`NCT02916914` - Impact of Feeding Interval of Preterms on the Time of Transition From Tube Feeding to Oral Feeding	N/A
Not yet recruiting	`NCT06335524` - Infant-Maternal Partnership and Cognitive Training Study for Preterm Infants	N/A
Completed	`NCT00419588` - Growth of Airways and Lung Tissues in Premature and Healthy Infants
Completed	`NCT05217186` - Associations Between Early Neonatal Neuroimaging, Hammersmith Infant Neurological Examination and General Movements
Completed	`NCT04886310` - Peabody Developmental Motor Scale-2 in 0 - 24 Months in Turkey
Enrolling by invitation	`NCT04478487` - Novel Human Milk Based Human Milk Fortifier	N/A
Not yet recruiting	`NCT05592431` - Effect of Volume Guarantee-High Frequency Oscillatory Ventilation on Cerebral Blood Flow in Neonates	N/A
Enrolling by invitation	`NCT05011071` - The Alberta BLOOM Premature Child Study
Completed	`NCT04889846` - The Effects of SAFE Early Intervention Approach in Premature Infants in Turkey	N/A
Recruiting	`NCT04064398` - Evaluation of Gastric Residuals and Feedings Progression	N/A
Completed	`NCT04500353` - Routine Or Selective Application of a Face Mask for Preterm Infants at Birth: the ROSA Trial	N/A
Completed	`NCT04247308` - Multi Modal Stimulations in Pre-term Neonates	N/A
Completed	`NCT03860142` - Evolution of Food Orality in Children Aged Between 24 and 36 Months: Comparison of the Severity and Specificities of Disorders Between Two Populations of Children, Born Very Prematurely and Born at Term
Completed	`NCT04234152` - Complete Shielding of Multivitamins to Reduce Toxic Peroxides in the Parenteral Nutrition: A Pilot Study	N/A
Terminated	`NCT04641000` - The Alberta BLOOM Long Term Follow Up Study
Completed	`NCT04284891` - Critical Respiratory Diseases in Ex-preterm Infants in PICU
Completed	`NCT04327466` - Effect of High Frequency Oscillatory Highflow Nasal Cannula on Desaturations and Bradycardia in Preterm Infants	N/A
Completed	`NCT00062452` - Esophageal Motility and Airway Defenses Among Infants	N/A
Completed	`NCT00579943` - Regulation of Cerebral Blood Flow in Very Low Birth Weight Infants	N/A