In Vitro Fertilization Clinical Trial
Official title:
Can Calcium Ionophore Application Enhance the ICSI Outcomes in Severe Male Factor Infertility?
The purpose of this study is to determine the impact of the use of calcium ionophore on the ICSI outcomes in couples with severe male factor infertility. Investigators conduct a randomized controlled trial on the sibling oocyte to justify the use of calcium ionophore in these cases.
Elevation of calcium levels inside the oocyte is one of the most initial steps which takes
place during normal fertilization (1). The interaction between the sperm and oocytes surface
protein receptors may be the triggering event for oocyte activation during the process of
fertilization (2). It is suggested that the process of intracellular Calcium elevation is
triggered by binding of the sperm to the oocyte oolemma and hence the fertilization starts
(3). Severe male factor couples might have compromised fertilization and pregnancy outcomes
(4).
A prospective multicenter non-randomized study indicated that calcium ionophore could
improve the fertilization as well as the clinical pregnancy rates in these patients (5). On
the other hand, a randomized controlled trial did not find any significance for the use of
calcium ionophore in the couples with poor ovarian reserve with regards the fertilization
and clinical pregnancy rates (6). The purpose of this study is to determine the impact of
the use of calcium ionophore on the ICSI outcomes in couples with severe male factor
infertility. Investigators conduct a randomized controlled trial on the sibling oocyte to
justify the use of calcium ionophore in these cases.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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