Impaired Glucose Tolerance Clinical Trial
Official title:
Assessment of the Effect of Artificial Sweeteners on Gut Microbiota and Glucose Metabolism
The Objectives of this study is to determine the effect(s) of daily non-caloric artificial sweetener (NAS) consumption (sucralose or aspartame) on the composition of the bacteria and also to determine the changes in glucose metabolism.
The trial will be 12 weeks randomized, cross-over and double blinded with 2 treatment
intervention ( sucralose and aspartame) , there will be a run in period (4 weeks), then phase
1 treatment period for two weeks followed by four weeks washout period then phase 2 treatment
period(2 weeks). Healthy, normglycemic (<5.6 mmol/L) males and females ( 17 total) of age
18-45 y with a body mass index (BMI) 20-25 kg/m2 will be recruited.
Each participants will be given the dose of sweetener aspartame or sucralose during the
treatment phase in a double-blind procedure.
the participant will be asked to consume the sweetener in a mixed flavoured beverage during
each visit in the treatment phase.
Blood and stool sample collection will take place before after the run-in period, and after
the washout period, as well as after each two-week treatment period.
glucose measurement: Capillary blood will be collected during each visit by registered nurse.
Blood will be collected at fasting and at 12,30,45,60,90 and 120 minutes after the
participants drink a glucose drink (75g glucose) for Oral glucose tolerance test.
a food frequency questionnaire will be given to each participant in order to estimate how
often each sweetener is consumed on a daily basis.
Participants will also be asked to complete weekly food diaries of food and drink
consumption.
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