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Clinical Trial Summary

This is a single-center, multidisciplinary, open-label, single-arm prospective clinical study.


Clinical Trial Description

In this study, 51 patients with hypohparyngeal carcinoma will be enrolled, These patients who have locally advanced-stage disease, including TNM stage cT3-4aN0-2M0 (AJCC 7th) and require a total laryngectomy as an initial therapy. Patients who achieved a CR or PR at the primary site after three cycles of TPF-regimen chemotherapy combined with immuotherapy will be referred for definitive RT and immuotherapy, while patients who received an evaluation of PD or SD at the primary site were referred for surgery followed by adjuvant RT/CRT. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04156698
Study type Interventional
Source Eye & ENT Hospital of Fudan University
Contact
Status Active, not recruiting
Phase Phase 2
Start date May 21, 2020
Completion date January 16, 2026

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