Immune Response Clinical Trial
Official title:
Investigating the Time of Nelfinavir Treatment Necessary for an Increase in Thymic Naive T Cells in Adults.
Our group has shown that HAART increases the thymic production of naïve T cells in the healthy adult, thereby boosting the immune system. We propose to investigate the amount of and length of Nelfinavir therapy necessary to increase those cells in adults. Subjects will be treated with Nelfinavir, and blood will be sampled at variable times to determine the immune response in peripheral blood.
Blood will be collected at several time points during the study. DNA will be isolated from
peripheral blood lymphocytes (PBL) and assessed for signal point (sj) TREC content relative
to genomic CCR5 copies by real time PCR in a spectoflourometic thermal cycler. TREC values
will be expressed as TREC copy number per copies of CCR5 or TREC/PBLs.
We anticipate that we will confirm our previous observations that nelfinavir therapy will
increase TRECs, indicating naive T cell production from the thymus. The proposed study will
determine the time course of the anticipated increase in TREC/PBLs.
;
Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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