Idiopathic Pulmonary Fibrosis Clinical Trial
Official title:
Prospective Study of Fibrosis In the Lung Endpoints (PROFILE - Central England)
The overall aim of this study is to develop a test that predicts the prognosis of IPF (Idiopathic Pulmonary Fibrosis) and which could be used to determine whether new treatments for IPF are likely to work.
The overall objectives of this study are
- Discover and validate novel biomarkers and gene expression profiles for use in
subsequent intervention studies in patients with IPF
- To prospectively validate a panel of previously published biomarkers in patients with
well characterized idiopathic fibrosing lung disease
- Investigate genetic associations and epigenetic modifications which affect disease
severity and progression
- Prospectively evaluate longitudinal disease behaviour in patients with IPF and NSIP with
a view to developing composite clinical end-points for subsequent use in intervention
studies in patients with IPF
Biomarkers that can be used for the following purposes will be identified:
- Identify patients (Diagnostic)(e.g. discriminate between health and disease)
- Correlate with disease severity (extent of disease, staging of disease)
- Predict clinical progression (Prognostic)(stable vs progressive disease)
- Track response to therapy (Therapeutic response)- Predict response to known efficacious
treatments & Correlates with changes in clinical endpoints/mortality/quality of life
- Predict risk of exacerbations (could be used to prevent exacerbations or reduce their
severity)
- Correlate with complications and/or comorbidities (e.g. biomarkers of Pulmonary Arterial
Hypertension, Gastro Oesophageal Reflux in IPF, etc)
;
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