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Clinical Trial Summary

Primary Objective: To assess the safety profile of autologous MitoCell administered to subjects with idiopathic Parkinson's disease (PD) Secondary Objective: To explore the efficacy and safety of MitoCell given as the recommended dose by stereotactic intrastriatal implantation


Clinical Trial Description

MitoCell is an autologous stem cell product that cultures with the company's unique patented medium. The mechanism of action of MitoCell is to improve the brain microenvironment in neurodegenerative disease. MitoCell which like mesenchymal stem cells modulate the immune response, and secrete more BDNF and SDF-1 neurotrophic factors than regular stem cell products.Therefore, MitoCell can protect and repair damaged dopamine neurons (DA) and stimulate DA regeneration.This project is a phase I open-label dose-escalation study to evaluate the safety, tolerability, and efficacy of autologous MitoCell intracranial transplantation in subjects with idiopathic Parkinson's disease which rating from stage 3 ~ 4 of modified Hoehn & Yahr staging. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05094011
Study type Interventional
Source Taiwan Mitochondrion Applied Technology Co., Ltd.
Contact Kuo-Wei Hsueh, Ph. D.
Phone 886-03-5820208
Email fskenneth@taimito.com
Status Not yet recruiting
Phase Phase 1
Start date March 1, 2025
Completion date July 31, 2027

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