Idiopathic Infertility Clinical Trial
Official title:
Neotililty Trial: Effect of Coenzyme Q10 on Semen Parameters in Men With Idiopathic Infertility
To study the effect of coenzyme Q10 on semen parameters in men with idiopathic infertility
Decreased serum CoQ10 concentrations as well as a decrease in the CoQ10H2 to-ubiquinone ratio
have been demonstrated in diseases associated with OS. A strong correlation among sperm
count, motility and ubiquinol-10 levels in seminal fluid has also been reported.
The aim of the present study is to investigate whether the effects of the exogenous
administration of ubiquinol in the improvement of semen parameters in Pakistani men
population.
Patients who full filled the inclusion criteria and gave informed written consent will be
included in the trial. Patient will start to take medication and will take it for 26 weeks.
All men undergo a thorough physical examination, a detail history, serum biochemical and
hematological laboratory tests and measurement of serum sex and thyroid hormone levels. A
questionnaire will be used to collect information on demographic characteristics. Two semen
samples 1 and 2 month apart will be obtained after 3 to 5 days of sexual abstinence and
process within 1 hour of ejaculation. The mean of the two will be used for statistical
analysis. Semen analyses will be performed using WHO recommended methods.
3 ml of blood will be withdrawn from the patient for the serum hormones analysis and total
amount of semen will required for analysis of semen parameters.
Sponsor will bear the test cost of patient during the study treatment period.
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