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ICU clinical trials

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NCT ID: NCT06425692 Not yet recruiting - Learning Clinical Trials

Work Package 3 Education for ICU Clinicians in Basic Palliative Care

Start date: September 1, 2024
Phase: N/A
Study type: Interventional

The EPIC project aims at sustainably improving palliative care for seriously ill patients and their families in ICUs. To this aim, an interdisciplinary consortium is working together to provide a new practical palliative care model using telemedicine. The project is the first European intervention study on palliative care in the ICU using a systems- based approach with proactive patient identification, checklist and blended learning designed to meet the specific needs of ICU staff. EPIC's vision is to contribute to a change in awareness from a narrow focus on prolonging life to a more holistic approach to care. The development of blended learning for intensive care staff is the task of Work Package (WP) 3. The aim is to improve the attitude, understanding and self-confidence of ICU staff. Blended learning is to be developed and implemented for this purpose. The aim is to teach the basics of palliative care on a cognitive, affective and psychomotor level. Due to the international character of the project, it is to be developed in English with subtitles in the local languages. In addition a workshop with patient and family advisors will be conducted.

NCT ID: NCT06163976 Recruiting - Older Adults Clinical Trials

Prognostic Modelling for Prediction of Mortality and Functional Disability in Critically-ill Elderly Patients

MYELDERLYICU
Start date: July 13, 2022
Phase:
Study type: Observational

Prospective observational study recruiting elderly patients of 60 years and above admitted to Intensive Care Unit (ICU), to study multiple domains of biomarkers ability to predict mortality of patients during intensive care unit admission and functional disability in survivors after ICU discharge

NCT ID: NCT06117046 Recruiting - Myocardial Injury Clinical Trials

Cardioprotective Effects of Cardiopeptides for Injection in Patients With Non-severe Cardiac Disease: a Single-center Randomized Controlled Trial

Start date: February 27, 2023
Phase: Phase 4
Study type: Interventional

The study was a single-center, randomized controlled trial. To explore the cardioprotective effect of cardiopeptide on non-heart disease patients with severe cardiac injury by comparing whether cardiopeptide was used.

NCT ID: NCT05606315 Recruiting - Sedation Clinical Trials

RemImazolam Besylate for ICU-sedation in Patients With Mechanical Ventilation After Oral and Maxillofacial Surgery

Start date: March 16, 2022
Phase: Phase 4
Study type: Interventional

Remimazolam besylate, as a new benzodiazepine drug, showing rapid clearance and moderate distribution of pharmacokinetic changes. The study will further explore the safety and effectiveness of remimazolam besylate n the sedation of mechanically ventilated patients after oral and maxillofacial surgery in the ICU.

NCT ID: NCT05600478 Completed - ICU Clinical Trials

Physical Therapy in the Intensive Care Unit: A Comparative Study of Three Asian Countries

Start date: November 6, 2021
Phase:
Study type: Observational

This descriptive-comparative study has explored and presented an overview of the extent of PT practice in the ICU in JP, PH, and TW. Specifically, the socio-demographic and ICU-related profiles of physical therapists (PTs) in Japan (JP), Philippines (PH), and Taiwan (TW) were presented, with the inclusion of the common PT interventions and challenges encountered in delivering PT services in the ICU in the said countries. Included in the socio-demographic variables are the respondents' sex, age, highest educational attainment, PT work experience, and hospital affiliation. As to the ICU-related variables, it includes the respondents' ICU work experience, the types of ICU where respondents primarily work, the hiring department they belong to, the status of ICU posting, the duration of ICU posting, the daily ICU stay of the respondents, their engagement in on-call ICU PT services, the usual source of ICU patient referral, the number of daily ICU patients, the ratio of PT to ICU patients, and the level of participation in ICU-related PT training. Furthermore, different interventions that are commonly implemented and challenges that are commonly encountered in ICU PT service delivery in Japan, Philippines, and Taiwan were also investigated.

NCT ID: NCT05559970 Recruiting - Clinical trials for Mechanical Ventilation

Inhalational Sedation and Mechanical Power

Start date: November 15, 2022
Phase: N/A
Study type: Interventional

Analgosedation is usually given to critically ill patients admitted in ICU. Fentanyl is the most common agent used for this purpose. For sedative agent, midazolam and propofol are commonly administered. However, too much sedation is apparently associated with increased duration of mechanical ventilation, prolonged ICU stay, and increased mortality. In mechanically ventilated patients, mechanical power is the respiratory mechanic that can predict clinical outcomes including mortality in both ARDS and non-ARDS patients. Previous study demonstrated that sedating mechanically ventilated patients with propofol could decreased mechanical power. This was possibly associated with improved clinical outcomes in these patients. At present, there is no clinical study investigating effects of inhalation sedation on mechanical power and clinical outcomes in mechanically ventilated patients.

NCT ID: NCT05283590 Recruiting - Cardiac Surgery Clinical Trials

Automated Inferior Vena Cava Collapsibility Index Fluid Responsiveness in Ventilated Patients After Cardiac Surgery.

Start date: February 12, 2022
Phase:
Study type: Observational

Echocardiographic measurement of inferior vena cava (IVC) collapsibility index (CI) with automated software analyses has been introduced. This study aims to assess the accuracy of IVC-CI (caval index) measurements as well as the ability to track fluid responsiveness (FRes) over time comparing the automated echocardiographic method with the pulse pressure variation (PPV) technique and the manual echocardiographic method in cardiac surgery patients.

NCT ID: NCT05248035 Recruiting - Delirium Clinical Trials

PupillOmetry for Prediction of DelirIUM

PODIUM
Start date: April 15, 2022
Phase:
Study type: Observational

Delirium in intensive care unit (ICU) is a serious event. It is associated with short-term complications (agitation, self-extubation, accidental removal of catheters, prolonged length of stay and ventilation), excess mortality, functional and cognitive impairment. It is particularly frequent in patients requiring mechanical ventilation but diagnosis is not easy. There are screening scales, but it is insufficiently used in clinical practice: Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) or Intensive Care Delirium Screening Checklist (ICDSC). These scales are time consuming and require trained personnel. Automated pupillometry (AP) is a new device to objectively, rapidly, and reproducibly identify acute brain dysfunction. Recent data suggest that AP could be used to predict delirium in the ICU. This would need to be validated for routine use in the ICU. Evaluate AP parameters on day 3 of invasive mechanical ventilation as a predictive tool for CAM-ICU diagnosed delirium during the first 14 days of ICU stay. Study design: Prospective, multicenter, non-interventional cohort Measurement of the AP parameters at day 3 after ICU admission and their predictive performance for delirium: pupillary diameter, variation of the pupillary diameter, pupillary constriction speed, pupillary dilatation speed, photomotor reflex latency, NPi and symmetry of pupillary responses.

NCT ID: NCT04944537 Active, not recruiting - Trauma Injury Clinical Trials

Current Situation and Analysis of ICU Management for Severe Trauma Patients in China

NJJLISTP
Start date: May 27, 2021
Phase:
Study type: Observational

Over the past 10 years, there has not been a consensus on ICU nursing management based on the concept of injury control. Case management for patients with serious trauma continues to be initiated in general services and after discharge.There is no critical care unit case management strategy for the high-risk population following acute intake. Consequently, there is an urgent need to develop and enhance ICU nursing best practice after injury control.

NCT ID: NCT04940208 Completed - Neuropathic Pain Clinical Trials

Chronic Pain in COVID-19 Patients Discharged From Intensive Care Unit

Start date: January 11, 2021
Phase:
Study type: Observational

More than six million French were affected by SARS-COV2 epidemic. About 20% of infected peoples were hospitalized, and about 5% were admitted to the intensive care units (ICU) for severe SARS-COV2 acute respiratory distress syndrome (ARDS) management. A spectrum of neuropsychiatric sequelae, specific for the ICU exposure, was already described, including post-intensive care syndrome and persistent pain. A growing body of evidence suggests the impact of SARS-COV2 exposure on the occurrence of neurological disorders and chronic pain syndrome development in COVID-19 patients. Taking together, one can expect a large number of patients discharged from ICU after severe COVID-19 with high prevalence of persistent pain and psychological disorders. To date, no study has evaluated neither the incidence of persistant pains in ICU COVID-19 survivors, nor pain phenotypes. The knowledge of such data is crucial in order to anticipate the management of such patients by specialized pain team, and to quantify the possible incurred burden of care. Our study aims to evaluate the incidence of pain, pain localization and severity, associated pain-related psychological disorders, and to perform quantitative sensory testing in severe COVID-19 patients, admitted to the ICU for more than 48 hours and successfully discharged home during the first French pandemic wave.